Effects of simvastatin on the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia

被引：4

作者：

Ozerova, IN ^{[1
]}

Paramonova, IV ^{[1
]}

Olfer'ev, AM ^{[1
]}

Akhmedzhanov, NM ^{[1
]}

Aleksandrova, MA ^{[1
]}

Perova, NV ^{[1
]}

机构：

[1] Russian Minist Hlth, State Res Ctr Prevent Med, Dept Metab Disorders, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 132卷 / 02期

关键词：

lipoproteins; phospholipids; hypercholesterolemia; simvastatin;

D O I：

10.1023/A:1013034029290

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia before and after treatment with simvastatin. Individual phospholipids were separated by thin-layer chromatography on glass plates coated with silica gel. It was found that apart from hypolipidemic effect, simivastatin changed the concentration and phospholipid composition of high-density lipoproteins, which improved their cholesterol-accepting and cholesterol-transporting properties.

引用

页码：763 / 765

页数：3

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