In situ Sensing of Single Binding Events by Localized Surface Plasmon Resonance

被引：120

作者：

Sannomiya, Takumi ^{[1
]}

Hafner, Christian ^{[1
]}

Voros, Janos ^{[1
]}

机构：

[1] ETH, Dept Informat Technol & Elect Engn, CH-8092 Zurich, Switzerland

来源：

NANO LETTERS | 2008年 / 8卷 / 10期

关键词：

D O I：

10.1021/nl802317d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single binding events of nanoparticle-labeled DNA strands were detected as stepwise peak shifts in localized surface plasmon resonance by single particle measurement. We confirmed the number of binding events by observing label particles by scanning electron microscopy. Our simulation based on a multiple multipole program showed that the peak shift is dependent on interparticle gap size and binding position. The experimental peak shift distribution was also reproduced by simulation.

引用

页码：3450 / 3455

页数：6

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