New Efficient Synthesis of 2,3,5-Trisubstituted Pyrimidin-4(3H)-ones from Baylis-Hillman Adducts

被引：12
作者：
Zhong, Ying [1 ]
Wu, Lei [1 ]
Ding, Ming-Wu [1 ]
机构：
[1] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2012年 / 44卷 / 19期
基金：
中国国家自然科学基金;
关键词：
azides; heterocycles; cyclizations; Wittig reactions; amines; alcohols; phenols; DERIVATIVES; ANTAGONISTS; CONSTRUCTION;
D O I：
10.1055/s-0032-1317034
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Azides obtained from Baylis-Hillman adducts were treated with triphenylphosphine to give the corresponding iminophosphoranes that underwent aza-Wittig reactions with aryl isocyanates and then reacted with amines, alcohol, or phenols in the presence of catalytic amounts of sodium alkoxide or potassium carbonate to give the corresponding 2,3,5-trisubstituted pyrimidin-4(3H)-ones directly in good yields.
引用
收藏
页码：3085 / 3089
页数：5
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