New Efficient Synthesis of 2,3,5-Trisubstituted Pyrimidin-4(3H)-ones from Baylis-Hillman Adducts

被引：12

作者：

Zhong, Ying ^{[1
]}

Wu, Lei ^{[1
]}

Ding, Ming-Wu ^{[1
]}

机构：

[1] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 19期

基金：

中国国家自然科学基金;

关键词：

azides; heterocycles; cyclizations; Wittig reactions; amines; alcohols; phenols; DERIVATIVES; ANTAGONISTS; CONSTRUCTION;

D O I：

10.1055/s-0032-1317034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Azides obtained from Baylis-Hillman adducts were treated with triphenylphosphine to give the corresponding iminophosphoranes that underwent aza-Wittig reactions with aryl isocyanates and then reacted with amines, alcohol, or phenols in the presence of catalytic amounts of sodium alkoxide or potassium carbonate to give the corresponding 2,3,5-trisubstituted pyrimidin-4(3H)-ones directly in good yields.

引用

页码：3085 / 3089

页数：5

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