Exploiting multimode waveguides for pure fibre-based imaging

被引:471
作者
Cizmar, Tomas [1 ]
Dholakia, Kishan [2 ]
机构
[1] Univ St Andrews, Sch Med, St Andrews KY16 9TF, Fife, Scotland
[2] Univ St Andrews, Sch Phys & Astron, SUPA, St Andrews KY16 9SS, Fife, Scotland
来源
NATURE COMMUNICATIONS | 2012年 / 3卷
关键词
LIGHT; MICROSCOPE; TRANSMISSION; BEAM;
D O I
10.1038/ncomms2024
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
There has been an immense drive in modern microscopy towards miniaturization and fibre-based technology. This has been necessitated by the need to access hostile or difficult environments in situ and in vivo. Strategies to date have included the use of specialist fibres and miniaturized scanning systems accompanied by ingenious microfabricated lenses. Here we present a novel approach for this field by utilizing disordered light within a standard multimode optical fibre for lensless microscopy and optical mode conversion. We demonstrate the modalities of bright-and dark-field imaging and scanning fluorescence microscopy at acquisition rates that allow observation of dynamic processes such as Brownian motion of mesoscopic particles. Furthermore, we show how such control can realize a new form of mode converter and generate various types of advanced light fields such as propagation-invariant beams and optical vortices. These may be useful for future fibre-based implementations of super-resolution or light-sheet microscopy.
引用
收藏
页数:9
相关论文
共 35 条
  • [1] Laser-guided assembly of heterotypic three-dimensional living cell microarrays
    Akselrod, G. M.
    Timp, W.
    Mirsaidov, U.
    Zhao, Q.
    Li, C.
    Timp, R.
    Timp, K.
    Matsudaira, P.
    Timp, G.
    [J]. BIOPHYSICAL JOURNAL, 2006, 91 (09) : 3465 - 3473
  • [2] Generation of a beam with a dark focus surrounded by regions of higher intensity: the optical bottle beam
    Arlt, J
    Padgett, MJ
    [J]. OPTICS LETTERS, 2000, 25 (04) : 191 - 193
  • [3] A quantum gas microscope for detecting single atoms in a Hubbard-regime optical lattice
    Bakr, Waseem S.
    Gillen, Jonathon I.
    Peng, Amy
    Foelling, Simon
    Greiner, Markus
    [J]. NATURE, 2009, 462 (7269) : 74 - U80
  • [4] BERCI G, 1995, SURG ENDOSC-ULTRAS, V9, P667
  • [5] A multi-mode fiber probe for holographic micromanipulation and microscopy
    Bianchi, Silvio
    Di Leonardo, Roberto
    [J]. LAB ON A CHIP, 2012, 12 (03) : 635 - 639
  • [6] Interference-free superposition of nonzero order light modes: Functionalized optical landscapes
    Cizmar, T.
    Dalgarno, H. I. C.
    Ashok, P. C.
    Gunn-Moore, F. J.
    Dholakia, K.
    [J]. APPLIED PHYSICS LETTERS, 2011, 98 (08)
  • [7] Optical aberration compensation in a multiplexed optical trapping system
    Cizmar, T.
    Dalgarno, H. I. C.
    Ashok, P. C.
    Gunn-Moore, F. J.
    Dholakia, K.
    [J]. JOURNAL OF OPTICS, 2011, 13 (04)
  • [8] Shaping the light transmission through a multimode optical fibre: complex transformation analysis and applications in biophotonics
    Cizmar, Tomas
    Dholakia, Kishan
    [J]. OPTICS EXPRESS, 2011, 19 (20): : 18871 - 18884
  • [9] In situ wavefront correction and its application to micromanipulation
    Cizmar, Tomas
    Mazilu, Michael
    Dholakia, Kishan
    [J]. NATURE PHOTONICS, 2010, 4 (06) : 388 - 394
  • [10] Tunable Bessel light modes: engineering the axial propagation
    Cizmar, Tomas
    Dholakia, Kishan
    [J]. OPTICS EXPRESS, 2009, 17 (18): : 15558 - 15570