Late Persistent Increased Putaminal 18F-DOPA Uptake Following Ipsilateral Frontal Resection Evidence for Corticostriatal Synaptic Plasticity?

被引:5
作者
Morana, Giovanni [1 ]
Piccardo, Arnoldo [2 ]
Garre, Maria Luisa [3 ]
Nobili, Flavio [4 ]
Rossi, Andrea [1 ]
机构
[1] Ist Giannina Gaslini, Neuroradiol Unit, I-16147 Genoa, Italy
[2] Osped Galliera, Dept Nucl Med, Genoa, Italy
[3] Ist Giannina Gaslini, Neurooncol Unit, I-16147 Genoa, Italy
[4] Univ Genoa, Dept Neurosci, Neurol Clin, Genoa, Italy
关键词
DIFFUSION;
D O I
10.1097/RLU.0000000000000798
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
We report the finding of late persistent increased putaminal F-18-3,4-dihydroxyphenylalanine (DOPA) uptake following resection of a high-grade glioma involving the lateral portion of the ipsilateral precentral gyrus. Brain MRI findings were consistent with secondary putaminal degeneration. This F-18-DOPA PET phenomenon possibly represents elevated presynaptic dopamine function secondary to upregulation of the amino acid decarboxylase (AADC) activity, as a compensatory mechanism in response to cortical injury. In the setting of brain tumor surveillance, focal increased striatal F-18-DOPA uptake should be carefully interpreted in light of MRI findings and pathological changes related to corticostriatal connections.
引用
收藏
页码:E451 / E452
页数:2
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