Late Persistent Increased Putaminal 18F-DOPA Uptake Following Ipsilateral Frontal Resection Evidence for Corticostriatal Synaptic Plasticity?

被引：5

作者：

Morana, Giovanni ^{[1
]}

Piccardo, Arnoldo ^{[2
]}

Garre, Maria Luisa ^{[3
]}

Nobili, Flavio ^{[4
]}

Rossi, Andrea ^{[1
]}

机构：

[1] Ist Giannina Gaslini, Neuroradiol Unit, I-16147 Genoa, Italy

[2] Osped Galliera, Dept Nucl Med, Genoa, Italy

[3] Ist Giannina Gaslini, Neurooncol Unit, I-16147 Genoa, Italy

[4] Univ Genoa, Dept Neurosci, Neurol Clin, Genoa, Italy

来源：

CLINICAL NUCLEAR MEDICINE | 2015年 / 40卷 / 09期

关键词：

DIFFUSION;

D O I：

10.1097/RLU.0000000000000798

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We report the finding of late persistent increased putaminal F-18-3,4-dihydroxyphenylalanine (DOPA) uptake following resection of a high-grade glioma involving the lateral portion of the ipsilateral precentral gyrus. Brain MRI findings were consistent with secondary putaminal degeneration. This F-18-DOPA PET phenomenon possibly represents elevated presynaptic dopamine function secondary to upregulation of the amino acid decarboxylase (AADC) activity, as a compensatory mechanism in response to cortical injury. In the setting of brain tumor surveillance, focal increased striatal F-18-DOPA uptake should be carefully interpreted in light of MRI findings and pathological changes related to corticostriatal connections.

引用

页码：E451 / E452

页数：2

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