Triterpenoids from Ganoderma lucidum and their cytotoxic activities

被引：63

作者：

Li, Peng ^{[1
]}

Deng, Yan-Ping ^{[2
]}

Wei, Xiao-Xia ^{[3
]}

Xu, Jian-Hua ^{[3
]}

机构：

[1] Fujian Med Univ, Fujian Prov Key Lab Pharmacol Nat Med, Sch Pharm, Fuzhou 350004, Peoples R China

[2] Fujian Med Univ, Inst Clin Pharmacol, Fuzhou 350004, Peoples R China

[3] Fujian Med Univ, Dept Pharmacol, Sch Pharm, Fuzhou 350004, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 01期

关键词：

Ganoderma lucidum; triterpenoid; cytotoxic activity; KARST;

D O I：

10.1080/14786419.2011.652961

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

From the ethyl acetate fraction of the fruiting body of Ganoderma lucidum, a new triterpenoid, ethyl 7 beta-hydroxy-4,4,14 alpha-trimethyl-3,11,15-trioxo-5 alpha-chol-8-en-24-oate (4), named ethyl lucidenates A, along with three known compounds, ganodermanondiol (1), lucidumol B (2) and methyl lucidenates A (3) were isolated by silica gel column, ODS column chromatography and PHPLC. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The isolated compounds were tested using in vitro MTT assay for their cytotoxic activities against the K562, HL-60, CA46, HepG2, SW480 and SMMC-7221 cancer cell lines. Among them, compound 4 showed cytotoxicity against HL-60 and CA46 cancer cell lines with IC50 values of 25.98 and 20.42?mu g?mL-1, respectively.

引用

页码：17 / 22

页数：6

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