Cation-exchange resin as an efficient hetero-geneous catalyst for one-pot three-component synthesis of 2,3-dihydro-4(1H)-quinazolinones

被引：16

作者：

Wang, M. ^{[1
]}

Zhang, T. T. ^{[1
]}

Gao, J. J. ^{[1
]}

Liang, Y. ^{[1
]}

机构：

[1] Bohai Univ, Coll Chem Chem Engn & Food Safety, Jinzhou 121000, Peoples R China

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2012年 / 48卷 / 06期

关键词：

2,3-dihydro-4(1H)-quinazolinones; isatoic anhydride; cation-exchange resin; multicomponent reactions; REUSABLE CATALYST; TUBULIN POLYMERIZATION; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; WATER; DERIVATIVES; QUINAZOLIN-4(3H)-ONES;

D O I：

10.1007/s10593-012-1073-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various mono- and disubstituted 2,3-dihydro-4(1H)-quinazolinones were synthesized efficiently by a one-pot three-component condensation of isatoic anhydride, aromatic aldehydes, and ammonium salts or primary amines using a strong acidic cation-exchange resin as the catalyst in EtOH-H2O solution. The catalyst is cheap, efficient, stable, and reusable under the reaction conditions. The novel method offers several advantages, such as excellent yields, environmentally friendly reaction media, and simple procedure.

引用

页码：897 / 902

页数：6

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