Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke

被引：76

作者：

Videen, TO

Zazulia, AR

Manno, EM

Derdeyn, CP

Adams, RE

Diringer, MN

Powers, WJ

机构：

[1] Washington Univ, Sch Med, E Bldg Imaging Ctr, Dept Neurol & Neurol Surg, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Neurol Neurosurg Intens Care Unit, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Lillian Strauss Inst Neurosci, Barnes Jewish Hosp St Louis, St Louis, MO 63110 USA

来源：

NEUROLOGY | 2001年 / 57卷 / 11期

关键词：

D O I：

10.1212/WNL.57.11.2120

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Changes in brain tissue volume in six patients who had acute complete middle cerebral artery (MCA) infarctions and CT evidence of midline shift were measured using the brain boundary shift integral (BBSI) on sequential Tl-weighted MR images acquired before and after a 1.5-g/kg bolus infusion of mannitol. At 50 to 55 minutes after the baseline scan, total brain volume decreased by 8.1 +/- 2.8 mL (0.6%, p < 0.005). Brain in the noninfarcted hemisphere shrank more (0.8 +/- 0.4%) than in the infarcted hemisphere (0.0 +/- 0.5%, p < 0.05).

引用

页码：2120 / 2122

页数：3

共 10 条

[1] HYPERTONIC UREA IN EXPERIMENTAL CEREBRAL EDEMA [J].