Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins

被引：29
作者：
Zeng, Meiqi [1 ]
Zheng, Manyin [1 ]
Lu, Desheng [1 ]
Wang, Jun [1 ]
Jiang, Wenqi [1 ,2 ,3 ,4 ]
Sha, Ou [1 ]
机构：
[1] Shenzhen Univ, Hlth Sci Ctr, Sch Med, Shenzhen 518060, Guangdong, Peoples R China
[2] Shenzhen Univ, Sch Med, Shenzhen 518060, Guangdong, Peoples R China
[3] State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China
[4] Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China
来源：
CHINESE JOURNAL OF CANCER | 2015年 / 34卷
关键词：
Ribosome-inactivating protein (RIP); Anti-tumor; Apoptosis; Cancer; CELLS IN-VITRO; NASOPHARYNGEAL CARCINOMA-CELLS; ACUTE LYMPHOBLASTIC-LEUKEMIA; RGEL/BLYS FUSION TOXIN; CANCER-CELLS; ALPHA-SARCIN; ASPERGILLUS-GIGANTEUS; ANTI-CD33; IMMUNOTOXIN; ANTICANCER ACTIVITY; SIGNALING PATHWAY;
D O I：
10.1186/s40880-015-0030-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.
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页数：10
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