Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins

被引：29
作者：
Zeng, Meiqi [1 ]
Zheng, Manyin [1 ]
Lu, Desheng [1 ]
Wang, Jun [1 ]
Jiang, Wenqi [1 ,2 ,3 ,4 ]
Sha, Ou [1 ]
机构：
[1] Shenzhen Univ, Hlth Sci Ctr, Sch Med, Shenzhen 518060, Guangdong, Peoples R China
[2] Shenzhen Univ, Sch Med, Shenzhen 518060, Guangdong, Peoples R China
[3] State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China
[4] Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China
来源：
CHINESE JOURNAL OF CANCER | 2015年 / 34卷
关键词：
Ribosome-inactivating protein (RIP); Anti-tumor; Apoptosis; Cancer; CELLS IN-VITRO; NASOPHARYNGEAL CARCINOMA-CELLS; ACUTE LYMPHOBLASTIC-LEUKEMIA; RGEL/BLYS FUSION TOXIN; CANCER-CELLS; ALPHA-SARCIN; ASPERGILLUS-GIGANTEUS; ANTI-CD33; IMMUNOTOXIN; ANTICANCER ACTIVITY; SIGNALING PATHWAY;
D O I：
10.1186/s40880-015-0030-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.
引用
收藏
页数：10
相关论文
共 50 条
  • [21] Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins
    Ho, Meng-Chiao
    Sturm, Matthew B.
    Almo, Steven C.
    Schramm, Vern L.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (48) : 20276 - 20281
  • [22] Anti-tumor mechanism of artesunate
    Fan, Xiaoyu
    Yan, Yiming
    Li, Yafei
    Song, Yu
    Li, Bo
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [23] Mechanism of the Specific Neuronal Toxicity of a Type I Ribosome-Inactivating Protein, Trichosanthin
    Sha, Ou
    Yew, David Tai-Wai
    Cho, Eric Yu-Pang
    Ng, Tzi-Bun
    Yuan, Lin
    Kwong, Wing-Hang
    NEUROTOXICITY RESEARCH, 2010, 18 (02) : 161 - 172
  • [24] Mechanism of the Specific Neuronal Toxicity of a Type I Ribosome-Inactivating Protein, Trichosanthin
    Ou Sha
    David Tai-Wai Yew
    Eric Yu-Pang Cho
    Tzi-Bun Ng
    Lin Yuan
    Wing-Hang Kwong
    Neurotoxicity Research, 2010, 18 : 161 - 172
  • [25] An apoptotic inducer, aralin, is a novel type II ribosome-inactivating protein from Aralia elata
    Tomatsu, M
    Kondo, T
    Yoshikawa, T
    Komeno, T
    Adachi, N
    Kawasaki, Y
    Ikuta, A
    Tashiro, F
    BIOLOGICAL CHEMISTRY, 2004, 385 (09) : 819 - 827
  • [26] The Cytotoxicity of Elderberry Ribosome-Inactivating Proteins Is Not Solely Determined by Their Protein Translation Inhibition Activity
    Shang, Chenjing
    Chen, Qiushi
    Dell, Anne
    Haslam, Stuart M.
    De Vos, Winnok H.
    Van Damme, Els J. M.
    PLOS ONE, 2015, 10 (07):
  • [27] Different neuronal toxicity of single-chain ribosome-inactivating proteins on the rat retina
    Sha, Ou
    Kwong, Wing Hang
    Cho, Eric Yu Pang
    Yew, David Tai Wai
    Ng, Tzi Bun
    TOXICON, 2008, 51 (01) : 45 - 53
  • [28] Different in vitro toxicities of structurally similar type I ribosome-inactivating proteins (RIPs)
    Sha, Ou
    Yew, David Tai Wai
    Ng, Tzi Bun
    Yuan, Lin
    Kwong, Wing Hang
    TOXICOLOGY IN VITRO, 2010, 24 (04) : 1176 - 1182
  • [29] Anti-tumor activities of matrine and oxymatrine: literature review
    Liu, Yan
    Xu, Yang
    Ji, Weidan
    Li, Xiaoya
    Sun, Bin
    Gao, Quangen
    Su, Changqing
    TUMOR BIOLOGY, 2014, 35 (06) : 5111 - 5119
  • [30] Ribosome-inactivating proteins from apple have strong aphicidal activity in artificial diet and in planta
    Hamshou, Mohamad
    Shang, Chenjing
    Smagghe, Guy
    Van Damme, Els J. M.
    CROP PROTECTION, 2016, 87 : 19 - 24
12345