Chronic constriction injury of the infraorbital nerve in the rat using modified syringe needle

被引：59

作者：

Kernisant, Melanie ^{[1
]}

Gear, Robert W. ^{[2
]}

Jasmin, Luc ^{[3
]}

Vit, Jean-Philippe ^{[3
]}

Ohara, Peter T. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Oral & Maxillofacial Surg, San Francisco, CA 94143 USA

[3] Cedars Sinai Med Ctr, Neurosurg & Gene Therapeut Res Inst, Los Angeles, CA 90048 USA

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2008年 / 172卷 / 01期

关键词：

CCI; ION; trigeminal ganglion; technique; neuropathy; chronic pain; animal model; microsurgery;

D O I：

10.1016/j.jneumeth.2008.04.013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we report a method for performing a chronic constriction injury (CCI) of the infraorbital nerve (ION) in the rat as a component of a chronic pain model. The surgical approach to the ION is described together with the use of a modified dental syringe needle that simplifies placing two chromic gut ligatures around the ION. This method makes the surgical procedure easier, the nerve injury more consistent across animals and reduces secondary damage to the ION and surrounding tissue. Pain behavior testing together with immunostaining for markers of nerve injury in the spinal trigeminal nucleus show the suitability of this procedure as a model of orofacial pain. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：43 / 47

页数：5

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