Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy?

被引：69
作者：
Walker, Lauren [1 ]
Sills, Graeme J. [1 ]
机构：
[1] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England
来源：
EPILEPSY CURRENTS | 2012年 / 12卷 / 01期
基金：
英国医学研究理事会;
关键词：
TEMPORAL-LOBE EPILEPSY; TOLL-LIKE RECEPTOR; MOBILITY GROUP BOX-1; HIPPOCAMPAL SCLEROSIS; CORTICAL DEVELOPMENT; RAT HIPPOCAMPUS; SEIZURES; HMGB1; CYTOKINES; BRAIN;
D O I：
10.5698/1535-7511-12.1.8
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Emerging data from experimental epilepsy models and resected human brain tissue support the proposed involvement of innate immune system activation and consequent inflammation in epilepsy. Key mediators of this process include interleukin-1 beta, high-mobility group box protein 1 (HMGB1), and Toll-like receptor (TLR) signaling. These recent findings constitute the basis for a novel avenue of drug development in epilepsy, one that is not only distinct from previous approaches but uniquely based on sound neurobiological evidence.
引用
收藏
页码：8 / 12
页数：5
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