Inflammation and Epilepsy: The Foundations for a New Therapeutic Approach in Epilepsy?

被引：67

作者：

Walker, Lauren ^{[1
]}

Sills, Graeme J. ^{[1
]}

机构：

[1] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England

来源：

EPILEPSY CURRENTS | 2012年 / 12卷 / 01期

基金：

英国医学研究理事会;

关键词：

TEMPORAL-LOBE EPILEPSY; TOLL-LIKE RECEPTOR; MOBILITY GROUP BOX-1; HIPPOCAMPAL SCLEROSIS; CORTICAL DEVELOPMENT; RAT HIPPOCAMPUS; SEIZURES; HMGB1; CYTOKINES; BRAIN;

D O I：

10.5698/1535-7511-12.1.8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Emerging data from experimental epilepsy models and resected human brain tissue support the proposed involvement of innate immune system activation and consequent inflammation in epilepsy. Key mediators of this process include interleukin-1 beta, high-mobility group box protein 1 (HMGB1), and Toll-like receptor (TLR) signaling. These recent findings constitute the basis for a novel avenue of drug development in epilepsy, one that is not only distinct from previous approaches but uniquely based on sound neurobiological evidence.

引用

页码：8 / 12

页数：5

共 53 条

[1] Cytokines and acute neurodegeneration [J].

Allan, SM ;

Rothwell, NJ .

NATURE REVIEWS NEUROSCIENCE, 2001, 2 (10) :734-744

[2] Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes [J].

Aloisi, F ;

Ria, F ;

Adorini, L .

IMMUNOLOGY TODAY, 2000, 21 (03) :141-147

[3] Introduction: HMGB1 in inflammation and innate immunity [J].

Andersson, U. ;

Rauvala, H. .

JOURNAL OF INTERNAL MEDICINE, 2011, 270 (04) :296-300

[4] Inflammation exacerbates seizure-induced injury in the immature brain [J].

Auvin, Stephane ;

Shin, Don ;

Mazarati, Andrey ;

Nakagawa, JoAnne ;

Miyamoto, Justin ;

Sankar, Raman .

EPILEPSIA, 2007, 48 :27-34

[5] Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA [J].

Auvin, Stephane ;

Shin, Don ;

Mazarati, Andrey ;

Sankar, Raman .

EPILEPSIA, 2010, 51 :34-38

[6] A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1β [J].

Balosso, Silvia ;

Maroso, Mattia ;

Sanchez-Alavez, Manuel ;

Ravizza, Teresa ;

Frasca, Angelisa ;

Bartfai, Tamas ;

Vezzani, Annamaria .

BRAIN, 2008, 131 :3256-3265

[7]

Becher B, 2000, GLIA, V29, P293

[8] CXCR4-activated astrocyte glutamate release via TNFa: amplification by microglia triggers neurotoxicity [J].

Bezzi, P ;

Domercq, M ;

Brambilla, L ;

Galli, R ;

Schols, D ;

De Clercq, E ;

Vescovi, A ;

Bagetta, G ;

Kollias, G ;

Meldolesi, J ;

Volterra, A .

NATURE NEUROSCIENCE, 2001, 4 (07) :702-710

[9] Dangers In and Out [J].

Bianchi, Marco E. ;

Manfredi, Angelo A. .

SCIENCE, 2009, 323 (5922) :1683-1684

[10] Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex [J].

Boer, K. ;

Jansen, F. ;

Nellist, M. ;

Redeker, S. ;

van den Ouweland, A. M. W. ;

Spliet, W. G. M. ;

van Nieuwenhuizen, O. ;

Troost, D. ;

Crino, P. B. ;

Aronica, E. .

EPILEPSY RESEARCH, 2008, 78 (01) :7-21

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