A General Strategy for Organocatalytic Activation of C-H Bonds via Photoredox Catalysis: Direct Arylation of Benzylic Ethers

被引：237
|
作者：
Qvortrup, Katrine [1 ]
Rankic, Danica A. [1 ]
MacMillan, David W. C. [1 ]
机构：
[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 02期
关键词：
PHOTOCHEMICALLY INDUCED REACTIONS; COUPLED ELECTRON-TRANSFER; ENOL ETHERS; ALIPHATIC-AMINES; BETA-ARYLATION; CHEMISTRY; PYRIDINEDICARBONITRILES; ALDEHYDES; ALKENES; KETONES;
D O I：
10.1021/ja411596q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Direct C-H functionalization and arylation of benzyl ethers has been accomplished via photoredox organocatalysis. The productive merger of a thiol catalyst and a commercially available iridium photoredox catalyst in the presence of household light directly affords benzylic arylation products in good to excellent yield. The utility of this methodology is further demonstrated in direct arylation of 2,5-dihydrofuran to form a single regioisomer.
引用
收藏
页码：626 / 629
页数：4
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