Specific Association of Type 1 Diabetes Mellitus With Anti-Cyclic Citrullinated Peptide-Positive Rheumatoid Arthritis

被引:64
作者
Liao, Katherine P. [1 ]
Gunnarsson, Marie [2 ]
Kallberg, Henrik [2 ]
Ding, Bo
Plenge, Robert M. [3 ,4 ]
Padyukov, Leonid [2 ,5 ]
Karlson, Elizabeth W.
Klareskog, Lars [2 ,5 ,6 ]
Askling, Johan [2 ,5 ]
Alfredsson, Lars [2 ]
机构
[1] Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA
[2] Karolinska Inst, Stockholm, Sweden
[3] MIT, Cambridge, MA 02139 USA
[4] Harvard Univ, Cambridge, MA 02138 USA
[5] Karolinska Hosp, S-10401 Stockholm, Sweden
[6] Stockholm Cty Council, Stockholm Ctr Publ Hlth, Stockholm, Sweden
来源
ARTHRITIS AND RHEUMATISM | 2009年 / 60卷 / 03期
基金
英国医学研究理事会;
关键词
SHARED EPITOPE ALLELES; AUTOIMMUNE-DISEASES; RISK LOCUS; GENE; PTPN22; SUSCEPTIBILITY; SMOKING; POPULATION; PADI4; CLASSIFICATION;
D O I
10.1002/art.24362
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. The co-occurrence of autoimmune diseases such as rheumatoid arthritis (RA) and type I diabetes mellitus (DM) has been reported in individuals and families. In this study, the strength and nature of this association were investigated at the population level in a Swedish case-control cohort. Methods. For this case-control study, 1,419 patients with incident RA diagnosed between 1996 and 2003 were recruited from university, public, and private rheumatology units throughout Sweden; 1,674 matched control subjects were recruited from the Swedish national population registry. Sera from the subjects were tested for the presence of antibodies to cyclic citrullinated peptide (anti-CCP), rheumatoid factor (RF), and the 620W PTPN22 allele. Information on a history of diabetes was obtained by questionnaire, telephone interview, and/or medical record review. The prevalence of type 1 DM and type 2 DM was compared between patients with incident RA and control subjects and further stratified for the presence of anti-CCP, RF, and the PTPN22 risk allele. Results. Type I DM was associated with an increased risk of RA (odds ratio [OR] 4.9, 95% confidence interval [95% CI] 1.8-13.1), and this association was specific for anti-CCP-positive RA (OR 7.3, 95% CI 2.7-20.0), but not anti-CCP-negative RA. Further adjustment for the presence of PTPN22 attenuated the risk of anti-CCP-positive RA in patients with type I DM to an OR of 5.3 (95% CI 1.5-18.7). No association between RA and type 2 DM was observed. Conclusion. The association between type I DM and RA is specific for a particular RA subset, anti-CCP-positive RA. The risk of developing RA later in life in patients with type I DM may be attributed, in part, to the presence of the 620W PTPN22 allele, suggesting that this risk factor may represent a common pathway for the pathogenesis of these 2 diseases.
引用
收藏
页码:653 / 660
页数:8
相关论文
共 40 条
[11]   Incidence of end-stage renal disease in patients with type 1 diabetes [J].
Finne, P ;
Reunanen, A ;
Stenman, S ;
Groop, PH ;
Grönhagen-Riska, C .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (14) :1782-1787
[12]   THE SHARED EPITOPE HYPOTHESIS - AN APPROACH TO UNDERSTANDING THE MOLECULAR-GENETICS OF SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS [J].
GREGERSEN, PK ;
SILVER, J ;
WINCHESTER, RJ .
ARTHRITIS AND RHEUMATISM, 1987, 30 (11) :1205-1213
[13]   A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene [J].
Hakonarson, Hakon ;
Grant, Struan F. A. ;
Bradfield, Jonathan P. ;
Marchand, Luc ;
Kim, Cecilia E. ;
Glessner, Joseph T. ;
Grabs, Rosemarie ;
Casalunovo, Tracy ;
Taback, Shayne P. ;
Frackelton, Edward C. ;
Lawson, Margaret L. ;
Robinson, Luke J. ;
Skraban, Robert ;
Lu, Yang ;
Chiavacci, Rosetta M. ;
Stanley, Charles A. ;
Kirsch, Susan E. ;
Rappaport, Eric F. ;
Orange, Jordan S. ;
Monos, Dimitri S. ;
Devoto, Marcella ;
Qu, Hui-Qi ;
Polychronakos, Constantin .
NATURE, 2007, 448 (7153) :591-U7
[14]   Association between PADI4 and rheumatoid arthritis:: a meta-analysis [J].
Iwamoto, T. ;
Ikari, K. ;
Nakamura, T. ;
Kuwahara, M. ;
Toyama, Y. ;
Tomatsu, T. ;
Momohara, S. ;
Kamatani, N. .
RHEUMATOLOGY, 2006, 45 (07) :804-807
[15]   Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis [J].
Kallberg, Henrik ;
Padyukov, Leonid ;
Plenge, Robert M. ;
Ronnelid, Johan ;
Gregersen, Peter K. ;
van der Helm-van Mil, Annette H. M. ;
Toes, Rene E. M. ;
Huizinga, Tom W. ;
Klareskog, Lars ;
Alfredsson, Lars .
AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (05) :867-875
[16]   A new model for an etiology of rheumatoid arthritis [J].
Klareskog, L ;
Stolt, P ;
Lundberg, K ;
Källberg, H ;
Bengtsson, C ;
Grunewald, J ;
Rönnelid, J ;
Harris, HE ;
Ulfgren, AK ;
Rantapää-Dahlqvist, S ;
Eklund, A ;
Padyukov, L ;
Alfredsson, L .
ARTHRITIS AND RHEUMATISM, 2006, 54 (01) :38-46
[17]   Association of STAM with rheumatoid arthritis in the Korean population [J].
Lee, Hye-Soon ;
Remmers, Elaine F. ;
Le, Julie M. ;
Kastner, Daniel L. ;
Bae, Sang-Cheol ;
Gregersen, Peter K. .
MOLECULAR MEDICINE, 2007, 13 (9-10) :455-460
[18]   Interaction between smoking, the, shared epitope, and anti-cyclic citrullinated peptide - A mixed picture in three large North American rheumatoid arthritis cohorts [J].
Lee, Hye-Soon ;
Irigoyen, Patricia ;
Kern, Marlena ;
Lee, Annette ;
Batliwalla, Franak ;
Khalili, Houman ;
Wolfe, Frederick ;
Lum, Raymond F. ;
Massarotti, Elena ;
Weisman, Michael ;
Bombardier, Claire ;
Karlson, Elizabeth W. ;
Criswell, Lindsey A. ;
Vlietinck, Robert ;
Gregersen, Peter K. .
ARTHRITIS AND RHEUMATISM, 2007, 56 (06) :1745-1753
[19]  
Mayfield J, 1998, AM FAM PHYSICIAN, V58, P1355
[20]   Rheumatoid arthritis, type 1 diabetes, and Graves' disease after acute parvovirus B19 infection [J].
Munakata, Y ;
Kodera, T ;
Saito, T ;
Sasaki, T .
LANCET, 2005, 366 (9487) :780-780