Systemic stress signalling: understanding the cell non-autonomous control of proteostasis

被引：127
作者：
Taylor, Rebecca C. [1 ]
Berendzen, Kristen M. [1 ]
Dillin, Andrew [1 ]
机构：
[1] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2014年 / 15卷 / 03期
关键词：
UNFOLDED PROTEIN RESPONSE; HEAT-SHOCK RESPONSE; CAENORHABDITIS-ELEGANS; LIFE-SPAN; MITOCHONDRIAL UPR; NEURONAL GPCR; LONGEVITY; ACTIVATION; DROSOPHILA; RESISTANCE;
D O I：
10.1038/nrm3752
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Proteome maintenance is crucial to cellular health and viability, and is typically thought to be controlled in a cell-autonomous manner. However, recent evidence indicates that protein-folding defects can systemically activate proteostasis mechanisms through signalling pathways that coordinate stress responses among tissues. Coordination of ageing rates between tissues may also be mediated by systemic modulation of proteostasis. These findings suggest that proteome maintenance is a systemically regulated process, a discovery that may have important therapeutic implications.
引用
收藏
页码：211 / 217
页数：7
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