Obeticholic acid: expanding the therapeutic landscape of NASH

被引:5
作者
Arrese, Marco [1 ]
Cabrera, Daniel [1 ]
Barrera, Francisco [1 ]
机构
[1] Pontificia Univ Catolica Chile, Escuela Med, Dept Gastroenterol, Santiago 8330024, Chile
关键词
FATTY LIVER-DISEASE; BILE-ACID; NUCLEAR RECEPTOR; NONALCOHOLIC STEATOHEPATITIS; INFLAMMATION; FXR;
D O I
10.1016/S1665-2681(19)31286-4
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:430 / 432
页数:3
相关论文
共 19 条
[1]   Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis [J].
Adorini, Luciano ;
Pruzanski, Mark ;
Shapiro, David .
DRUG DISCOVERY TODAY, 2012, 17 (17-18) :988-997
[2]   Long-Term Mortality in Nonalcoholic Fatty Liver Disease: Is Liver Histology of Any Prognostic Significance? [J].
Angulo, Paul .
HEPATOLOGY, 2010, 51 (02) :373-375
[3]   Nuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver Diseases [J].
Arrese, M. ;
Karpen, S. J. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2010, 87 (04) :473-478
[4]   New horizons in the regulation of bile acid and lipid homeostasis: critical role of the nuclear receptor FXR as an intracellular bile acid sensor [J].
Arrese, M ;
Karpen, SJ .
GUT, 2001, 49 (04) :465-466
[5]   FXR Agonists as Therapeutic Agents for Non-alcoholic Fatty Liver Disease [J].
Carr, Rotonya M. ;
Reid, Andrea E. .
CURRENT ATHEROSCLEROSIS REPORTS, 2015, 17 (04)
[6]   The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology [J].
Chalasani, Naga ;
Younossi, Zobair ;
Lavine, Joel E. ;
Diehl, Anna Mae ;
Brunt, Elizabeth M. ;
Cusi, Kenneth ;
Charlton, Michael ;
Sanyal, Arun J. .
GASTROENTEROLOGY, 2012, 142 (07) :1592-1609
[7]   Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid [J].
Hirschfield, Gideon M. ;
Mason, Andrew ;
Luketic, Velimir ;
Lindor, Keith ;
Gordon, Stuart C. ;
Mayo, Marlyn ;
Kowdley, Kris V. ;
Vincent, Catherine ;
Bodhenheimer, Henry C., Jr. ;
Pares, Albert ;
Trauner, Michael ;
Marschall, Hanns-Ulrich ;
Adorini, Luciano ;
Sciacca, Cathi ;
Beecher-Jones, Tessa ;
Castelloe, Erin ;
Boehm, Olaf ;
Shapiro, David .
GASTROENTEROLOGY, 2015, 148 (04) :751-U347
[8]   Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet [J].
Kong, Bo ;
Luyendyk, James P. ;
Tawfik, Ossama ;
Guo, Grace L. .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, 328 (01) :116-122
[9]   Bile acid receptors in non-alcoholic fatty liver disease [J].
Li, Yuanyuan ;
Jadhav, Kavita ;
Zhang, Yanqiao .
BIOCHEMICAL PHARMACOLOGY, 2013, 86 (11) :1517-1524
[10]   Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target [J].
Liu, Wen-Yue ;
Xie, Dong-Mei ;
Zhu, Gui-Qi ;
Huang, Gui-Qian ;
Lin, Yi-Qian ;
Wang, Li-Ren ;
Shi, Ke-Qing ;
Hu, Bin ;
Braddock, Martin ;
Chen, Yong-Ping ;
Zheng, Ming-Hua .
EXPERT OPINION ON THERAPEUTIC TARGETS, 2015, 19 (05) :675-685