Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance

被引：26
|
作者：
Zhang, Yue [1 ]
Qian, Huizhu [1 ]
He, Jing [1 ]
Gao, Wen [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, 300 Guangzhou Rd, Nanjing 210029, Peoples R China
来源：
BIOMARKER RESEARCH | 2020年 / 8卷 / 01期
基金：
中国国家自然科学基金;
关键词：
tRNA-derived fragments; tRNA halves; Cancer; Drug resistance; Biomarker; BOX-BINDING PROTEIN-1; PROMOTES CELL-PROLIFERATION; INTEGRIN-LINKED KINASE; BREAST-CANCER; LUNG-CANCER; OVARIAN-CANCER; P-GLYCOPROTEIN; CISPLATIN CHEMOSENSITIVITY; ANTIESTROGEN RESISTANCE; DOXORUBICIN RESISTANCE;
D O I：
10.1186/s40364-020-00233-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers. They enhance cell proliferation and metastasis or inhibit cancer progression. Many studies have investigated their roles in the diagnosis, progression, metastasis, and prognosis of various cancers, but the mechanisms through which they are involved in resistance to cancer treatment are unclear. This review outlines the classification of tRFs and tiRNAs and their mechanisms in cancer drug resistance, thus providing new ideas for cancer treatment.
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页数：14
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