The Olig family affects central nervous system development and disease

被引:12
|
作者
Tan, Botao [1 ]
Yu, Jing [1 ]
Yin, Ying [1 ]
Jia, Gongwei [1 ]
Jiang, Wei [1 ]
Yu, Lehua [1 ]
机构
[1] Chongqing Med Univ, Dept Rehabil Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
基金
中国国家自然科学基金;
关键词
nerve regeneration; brain injury; spinal cord injury; review; Olig family; oligodendrocytes; astrocytes; central nervous system disease; demyelination; development; differentiation; NSFC grant; neural regeneration; NEURAL STEM-CELLS; SPINAL-CORD-INJURY; BHLH TRANSCRIPTION FACTOR; OLIGODENDROCYTE PRECURSOR CELLS; MOTOR-NEURON; PROGENITOR CELLS; ASTROCYTE DEVELOPMENT; SUBVENTRICULAR ZONE; MALIGNANT GLIOMA; ADULT ZEBRAFISH;
D O I
10.4103/1673-5374.128232
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Neural cell differentiation and maturation is a critical step during central nervous system development. The oligodendrocyte transcription family (Olig family) is known to be an important factor in regulating neural cell differentiation. Because of this, the Olig family also affects acute and chronic central nervous system diseases, including brain injury, multiple sclerosis, and even gliomas. Improved understanding about the functions of the Olig family in central nervous system development and disease will greatly aid novel breakthroughs in central nervous system diseases. This review investigates the role of the Olig family in central nervous system development and related diseases.
引用
收藏
页码:329 / 336
页数:8
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