Genetic factors associated with gout and hyperuricemia

被引：36
作者：
Bleyer, AJ
Hart, TC
机构：
[1] Wake Forest Univ, Dept Internal Med, Sch Med, Nephrol Sect, Winston Salem, NC 27157 USA
[2] Natl Inst Dent & Craniofacial Res, Human Craniofacial Genet Sect, NIH, Bethesda, MD USA
来源：
ADVANCES IN CHRONIC KIDNEY DISEASE | 2006年 / 13卷 / 02期
关键词：
genetics; gout; hyperuricemia; medullary cystic kidney disease; uromodulin; familial juvenile hyperuricemic nephropathy;
D O I：
10.1053/j.ackd.2006.01.008
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Hyperuricemia and gout are common conditions that have long been known to have a heritable component. Obesity, diabetes, and chronic kidney failure are conditions with multifactorial inheritance that are associated with gout. In addition, social factors such as protein and alcohol intake affect serum uric acid levels. The current review discusses basic uric acid metabolism and the multigenetic inheritance of hyperuricemia. Several monogenic disorders affecting Uric acid metabolism are reviewed. The genetics, pathophysiology, diagnosis, and treatment of familial juvenile hyperuricemic nephropathy/medullary cystic kidney disease, autosomal dominant disorders associated with hyperuricemia and progressive kidney failure, are described. (c) 2006 by the National Kidney Foundation, Inc.
引用
收藏
页码：124 / 130
页数：7
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