Synthesis of chiral 1-(2-aminoalkyl)aziridines via a self-opening reaction of aziridine

被引：4

作者：

Pieczonka, Adam M. ^{[1
]}

Misztal, Ewelina ^{[1
]}

Rachwalski, Michal ^{[1
]}

Lesniak, Stanislaw ^{[1
]}

机构：

[1] Univ Lodz, Dept Organ & Appl Chem, Tamka 12, PL-91403 Lodz, Poland

来源：

ARKIVOC | 2017年

关键词：

Aziridine; diamine; aminoalkylaziridine; ring-opening of aziridine; ASYMMETRIC ADDITIONS; COMPLEXES; DIAMINES; ALCOHOLS; LIGAND; ALDEHYDES;

D O I：

10.3998/ark.5550190.p009.741

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach to the synthesis of optically pure 1-(2-aminoalkyl)aziridines via a nucleophilic ring-opening reaction of aziridine is presented. The reaction takes place under mild conditions in the presence of ZnBr2 with moderate chemical yields. The formation of 1-(2-aminoalkyl)aziridines, starting from optically pure NH-aziridines, occurs selectively, leading to a single diastereoisomer.

引用

页码：223 / 234

页数：12

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