Epigenetic regulation of cardiac fibrosis

被引：43
作者：
Tao, Hui [1 ]
Shi, Kai-Hu [1 ]
Yang, Jing-Jing [2 ,3 ]
Huang, Cheng [2 ]
Liu, Li-Ping [3 ]
Li, Jun [2 ]
机构：
[1] Anhui Med Univ, Hosp 2, Dept Cardiothorac Surg, Hefei 230601, Anhui, Peoples R China
[2] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
[3] Anhui Med Univ, Hosp 2, Dept Pharmacol, Hefei 230601, Peoples R China
来源：
CELLULAR SIGNALLING | 2013年 / 25卷 / 09期
关键词：
Epigenetics; DNA methylation; Histone modifications; MicroRNAs; Cardiac fibrosis; TO-MESENCHYMAL TRANSITION; DNA METHYLATION; HISTONE-DEACETYLASE; GENE-EXPRESSION; MYOFIBROBLAST DIFFERENTIATION; TRANSCRIPTIONAL REGULATION; MYOCARDIAL FIBROSIS; MICRORNA GENES; MESSENGER-RNA; HEART-FAILURE;
D O I：
10.1016/j.cellsig.2013.03.024
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cardiac fibrosis is characterized by excessive extracellular matrix accumulation that ultimately destroys tissue architecture and eventually abolishes normal function. In recent years, despite the underlying mechanisms of cardiac fibrosis are still unknown, numerous studies suggest that epigenetic modifications impact on the development of cardiac fibrosis. Epigenetic modifications control cell proliferation, differentiation, migration, and so on. Epigenetic modifications contain three main processes: DNA methylation, histone modifications, and silencing by microRNAs. We here outline the recent work pertaining to epigenetic changes in cardiac fibrosis. This review focuses on the epigenetic regulation of cardiac fibrosis. (C) 2013 Elsevier Inc All rights reserved.
引用
收藏
页码：1932 / 1938
页数：7
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