Diabetes mellitus, insulin treatment, diabetes duration, and risk of biliary tract cancer and hepatocellular carcinoma in a European cohort

被引：105

作者：

Schlesinger, S. ^{[1
,2
]}

Aleksandrova, K. ^{[2
]}

Pischon, T. ^{[2
,3
]}

Jenab, M. ^{[4
]}

Fedirko, V. ^{[4
,5
]}

Trepo, E. ^{[6
]}

Overvad, K. ^{[7
]}

Roswall, N. ^{[8
]}

Tjonneland, A. ^{[8
]}

Boutron-Ruault, M. C. ^{[9
,10
,11
]}

Fagherazzi, G. ^{[9
,10
,11
]}

Racine, A. ^{[9
,10
,11
]}

Kaaks, R. ^{[12
]}

Grote, V. A. ^{[12
]}

Boeing, H. ^{[2
]}

Trichopoulou, A. ^{[13
,14
]}

Pantzalis, M. ^{[14
]}

Kritikou, M. ^{[14
]}

Mattiello, A. ^{[15
]}

Sieri, S. ^{[16
]}

Sacerdote, C. ^{[17
]}

Palli, D. ^{[18
]}

Tumino, R. ^{[19
]}

Peeters, P. H. ^{[20
,21
]}

Bueno-de-Mesquita, H. B. ^{[22
,23
]}

Weiderpass, E. ^{[24
,25
,26
,27
]}

Quiros, J. R. ^{[28
]}

Zamora-Ros, R. ^{[29
]}

Sanchez, M. J. ^{[30
,31
]}

Arriola, L. ^{[31
,32
]}

Ardanaz, E. ^{[31
,33
]}

Tormo, M. J. ^{[31
,34
]}

Nilsson, P. ^{[35
]}

Lindkvist, B. ^{[36
,38
]}

Sund, M. ^{[37
]}

Rolandsson, O.

Khaw, K. T. ^{[39
]}

Wareham, N. ^{[40
]}

Travis, R. C. ^{[41
]}

Riboli, E. ^{[42
]}

Noethlings, U. ^{[43
,44
]}

机构：

[1] Univ Kiel, Inst Epidemiol, D-24105 Kiel, Germany

[2] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[3] Max Delbruck Ctr Mol Med Berlin Buch, Mol Epidemiol Grp, Berlin, Germany

[4] Int Agcy Res Canc IARC WHO, Lyon, France

[5] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

[6] Ctr Biol Republ, Lyon, France

[7] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark

[8] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[9] Ctr Res Epidemiol & Populat Hlth CESP, INSERM, U1018, Nutr Hormones & Womens Hlth Team, Villejuif, France

[10] Univ Paris Sud, UMRS 1018, Villejuif, France

[11] IGR, Villejuif, France

[12] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[13] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-10679 Athens, Greece

[14] Hellen Hlth Fdn, Athens, Greece

[15] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[16] Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Nutr Epidemiol Unit, Milan, Italy

[17] Human Genet Fdn HuGeF, Ctr Canc Prevent CPO Piemonte, Turin, Italy

[18] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[19] ASP Ragusa, Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[20] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[21] Univ London Imperial Coll Sci Technol & Med, Fac Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[22] RIVM, Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands

[23] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[24] Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[25] Canc Registry Norway, Oslo, Norway

[26] Dept Med Epidemiol & Biostat, Stockholm, Sweden

[27] Samfundet Folkhalsan, Dept Genet Epidemiol, Helsinki, Finland

[28] Publ Hlth Directorate, Asturias, Spain

[29] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Barcelona, Spain

[30] Andalusian Sch Publ Hlth, Granada, Spain

[31] CIBER Epidemiol & Salud Publ CIBERESP, Granada, Spain

[32] Basque Govt, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[33] Navarre Publ Hlth Inst, Pamplona, Spain

[34] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[35] Lund Univ, Univ Hosp, Dept Hlth Sci, Malmo, Sweden

[36] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden

[37] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[38] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[39] Univ Cambridge, Cambridge, England

[40] MRC, Epidemiol Unit, Cambridge, England

[41] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[42] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[43] Univ Bonn, Inst Nutr & Food Sci, Bonn, Germany

[44] Univ Kiel, Inst Expt Med, Epidemiol Sect, D-24105 Kiel, Germany

来源：

ANNALS OF ONCOLOGY | 2013年 / 24卷 / 09期

基金：

欧洲研究理事会;

关键词：

biliary tract neoplasms; diabetes duration; diabetes mellitus; gallbladder neoplasms; hepatocellular carcinoma; insulin treatment; PRIMARY LIVER-CANCER; OBESITY; DISEASE; METAANALYSIS; ASSOCIATION; VETERANS; STONES;

D O I：

10.1093/annonc/mdt204

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Evidence on associations between self-reported diabetes mellitus, diabetes duration, age at diabetes diagnosis, insulin treatment, and risk of biliary tract cancer (BTC) and hepatocellular carcinoma (HCC), independent of general and abdominal obesity is scarce. We conducted a prospective analysis in the EPIC-cohort study among 363 426 participants with self-reported diabetes data. Multivariable adjusted relative risks and 95% confidence intervals were estimated from Cox regression models. In a nested case-control subset, analyses were carried out in HCV/HBV-negative individuals. During 8.5 years of follow-up, 204 BTC cases [including 75 gallbladder cancer (GBC) cases], and 176 HCC cases were identified. Independent of body mass index and waist-to-height ratio diabetes status was associated with higher risk of BTC and HCC [1.77 (1.00-3.13) and 2.17 (1.36-3.47)]. For BTC, the risk seemed to be higher in participants with shorter diabetes duration and those not treated with insulin. Regarding cancer subsites, diabetes was only associated with GBC [2.72 (1.17-6.31)]. The risk for HCC was particularly higher in participants treated with insulin. The results were not appreciably different in HCV/HBV-negative individuals. This study supports the hypothesis that diabetes is a risk factor for BTC (particularly GBC) and HCC. Further research is required to establish whether diabetes treatment or duration is associated with these cancers.

引用

页码：2449 / 2455

页数：7

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