Standardised uptake values of 2-deoxy-2-[18F]fluoro-D-glucose using PET/CT in normal cats

In this study we assessed the normal physiological and dynamic thoracoabdominal distribution of F-18 fluorodeoxyglucose (F-18-FDG) uptake and the standardized uptake values (SUVs) of the major parenchymal organs in five normal young adult domestic short haired cats. Dynamic PET data were acquired with a transaxial field-of-view (FOV) PET/CT scanner, Regions of interests (ROIs) were manually drawn over the left ventricular free wall, left ventricular blood pool, liver, spleen, and left and right renal cortices. The SUVs of these organs were calculated for 5-min frames over the 90 mm acquisition. The uptake of F-18-FDG within the major organs, showed a tendency to gradually decline, except for the left ventricle and blood pool. The decrease in SUV was rapid after injection with a plateau occurring after 30 minutes. The uptake of F-18-FDG within the hepatic parenchyma was low compared to that in the kidney at the beginning of study. A steady decline in the hepatic parenchyma SUV was quite similar to that observed for the kidneys. The SUV of F-18-FDG within the spleen was low. Uptake of F-18-FDG within the myocardium was minimal. These SUV data from the parenchymal organs of normal cats compares favourably with those of normal humans and dogs and can be used in feline studies using PET/CT for the evaluation of various diseases. Furthermore, PET/CT can provide higher quality images over shorter examination times than conventional PET.