Design, synthesis and antiproliferative activity of some new azapyranoxanthenone aminoderivatives

被引：75
作者：
Kolokythas, G
Pouli, N
Marakos, P
Pratsinis, H
Kletsas, D
机构：
[1] Univ Athens, Dept Pharm, Div Pharmaceut Chem, GR-15771 Athens, Greece
[2] NCSR, Inst Biol, Lab Cell Proliferat & Ageing, Athens 15310, Greece
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 01期
关键词：
azapyranoxanthenones; cytotoxic activity; cell-cycle effect;
D O I：
10.1016/j.ejmech.2005.10.011
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some novel ammosubstituted azapyranoxanthenones, bearing structural similarity to the actidone alkaloid acronycine, have been designed and synthesized. Their in vitro cytotoxicities against the murine L 12 10 leukemia and the human solid tumor HT-29 cell lines have been investigated. Their eventual selective effect on a phase of the cell cycle was evaluated, using HT-29 cells. A number of the new derivatives exhibited interesting cytotoxic activity against the human solid tumor cell line. (c) 2005 Elsevier SAS. All rights reserved.
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页码：71 / 79
页数：9
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