Joint hypermobility is not positively associated with prevalent multiple joint osteoarthritis: a cross-sectional study of older adults

被引:7
作者
Gullo, Terese R. [1 ]
Golightly, Yvonne M. [2 ,3 ,4 ,5 ]
Flowers, Portia [2 ]
Jordan, Joanne M. [2 ,3 ,6 ]
Renner, Jordan B. [2 ,7 ]
Schwartz, Todd A. [2 ,11 ]
Kraus, Virginia B. [8 ]
Hannan, Marian T. [9 ,10 ]
Cleveland, Rebecca J. [2 ]
Nelson, Amanda E. [2 ,6 ]
机构
[1] Ohio State Univ, Coll Med, Columbus, OH 43210 USA
[2] Univ N Carolina, Thurston Arthrit Res Ctr, 3300 Doc J Thurston Bldg,Campus Box 7280, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Injury Prevent Res Ctr, Chapel Hill, NC 27599 USA
[5] Univ N Carolina, Div Phys Therapy, Chapel Hill, NC 27599 USA
[6] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA
[7] Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
[8] Duke Univ, Sch Med, Durham, NC USA
[9] Hebrew SeniorLife, Inst Aging Res, Boston, MA USA
[10] Harvard Med Sch, Boston, MA 02115 USA
[11] Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
基金
美国国家卫生研究院;
关键词
Hypermobility; Generalized osteoarthritis; Polyarticular osteoarthritis; SYMPTOMATIC KNEE OSTEOARTHRITIS; HAND OSTEOARTHRITIS; LUMBAR SPINE; ARTICULAR MOBILITY; LAXITY; PAIN; RISK; HIP; ARTHRITIS; FEATURES;
D O I
10.1186/s12891-019-2550-z
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Background: This cross-sectional study evaluated associations of joint hypermobility and multiple joint osteoarthritis (MJOA) in a community-based cohort of adults 45+ years of age. Methods: MJOA and joint hypermobility data were from 1677 participants (mean age 69years, 68% women) who completed research clinic visits during 2003-2010. Prevalent MJOA was defined in four ways. Radiographic OA (rOA) was defined as Kellgren-Lawrence (KL) >= 2 at any included study joint; symptomatic OA (sxOA) required both symptoms and rOA in a joint. Joint hypermobility was defined as a Beighton score of >= 4. Separate logistic regression models were used to estimate odds ratios (OR) between joint hypermobility and each MJOA definition, adjusting for age, sex, race, body mass index, and baseline visit. Results: In this cohort, 4% had Beighton score >= 4 and 63% met any definition of MJOA. Joint hypermobility was associated with significantly lower odds of radiographic and symptomatic MJOA-1 (multiple joint OA-definition 1: involvement of >= 1 IP (interphalangeal) nodes and >= 2 sites of hip, knee, and spine; 74 and 58% lower, respectively). However, for the other MJOA definitions (i.e., MJOA-2:involvement of >= 2 IP joints, >= 1 carpometacarpal [CMC] joints, and knee or hip sites; MJOA-3: involvement of >= 5 joint sites from among distal interphalangeal, proximal interphalangeal, CMC, hip, knee, or spine sites; and MJOA-4:involvement of >= 2 lower body sites (hip, knee, or spine), there were no statistically significant associations. For associations between site-specific hypermobility and any MJOA definition, most adjusted ORs were less than one, but few were statistically significant. Conclusions: Overall, joint hypermobility was not positively associated with any definition of prevalent MJOA in this cohort, and an inverse association existed with one definition of MJOA. Longitudinal studies are needed to determine the contribution of hypermobility to the incidence and progression of MJOA outcomes.
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页数:9
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