How does Parkinson's disease and aging affect temporal expectation and the implicit timing of eye movements?

被引:15
作者
de Hemptinne, C. [1 ]
Ivanoiu, A. [1 ,2 ]
Lefevre, P. [1 ,3 ,4 ]
Missal, M. [1 ]
机构
[1] Catholic Univ Louvain, Inst Neurosci IoNS, Pole Grp COSY, COSY, B-1200 Brussels, Belgium
[2] St Luc Univ Hosp, Dept Neurol, B-1200 Brussels, Belgium
[3] ICTEAM Inst Informat & Commun Technol Elect & App, B-1348 Louvain, Belgium
[4] Inst Neurosci IoNS, B-1348 Louvain, Belgium
关键词
Eye movements; Parkinson's disease; Expectation; Implicit timing; PURSUIT OCULAR MOVEMENTS; SMOOTH-PURSUIT; ANTICIPATORY PURSUIT; QUANTITATIVE-ANALYSIS; INHIBITORY CONTROL; OCULOMOTOR CONTROL; MOTOR DEFICITS; SACCADES; ABNORMALITIES; PREDICTION;
D O I
10.1016/j.neuropsychologia.2012.10.001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Anticipatory eye movements are often evoked by the temporal expectation of an upcoming event. Temporal expectation is based on implicit timing about when a future event could occur. Implicit timing emerges from observed temporal regularities in a changing stimulus without any voluntary estimate of elapsed time, unlike explicit timing. The neural bases of explicit and implicit timing are likely different. It has been shown that the basal ganglia (BG) play a central role in explicit timing. In order to determine the influence of BG in implicit timing, we investigated the influence of early Parkinson's disease (PD) and aging on the latency of anticipatory eye movements. We hypothesized that a deficit of implicit timing should yield inadequate temporal expectations, and consequently abnormally timed anticipatory eye movements compared with age-matched controls. To test this hypothesis, we used an oculomotor paradigm where anticipation of a salient target event plays a central role. Participants pursued a visual target that moved along a circular path at a constant velocity. After a randomly short (1200 ms) or long (2400 ms) forward path, the target reversed direction, returned to its starting position and stopped. Target motion reversal caused an abrupt 'slip' of the pursued target image on the retina and was a particularly salient event evoking anticipatory eye movements. Anticipatory eye movements were less frequent in PD patients. However, the timing of anticipation of target motion reversal was statistically similar in PD patients and control subjects. Other eye movements showed statistically significant differences between PD and controls, but these differences could be attributed to other factors. We conclude that all anticipatory eye movements are not similarly impaired in PD and that implicit timing of salient events seems largely unaffected by this disease. The results support the hypothesis that implicit and explicit timing are differently affected by BG dysfunction. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:340 / 348
页数:9
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