Oral delivery of natural compounds by phospholipid vesicles

被引：17

作者：

Manconi, Maria ^{[1
]}

Caddeo, Carla ^{[1
]}

Manca, Maria Letizia ^{[1
]}

Fadda, Anna Maria ^{[1
]}

机构：

[1] Univ Cagliari, Dept Life & Environm Sci, Via Osped 72, I-09124 Cagliari, Italy

来源：

NANOMEDICINE | 2020年 / 15卷 / 18期

关键词：

dehydrated vesicles; natural compounds; oral delivery; phospholipid vesicles; polymer-phospholipid association; polymer coating; proliposomes; SOLID LIPID NANOPARTICLES; N-SUCCINYL-CHITOSAN; COATED LIPOSOMES; OXIDATIVE STRESS; BIOAVAILABILITY; PROLIPOSOMES; QUERCETIN; CURCUMIN; NANOLIPOSOMES; HYALUROSOMES;

D O I：

10.2217/nnm-2020-0085

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The purpose of this report is to summarize and critically analyze emerging trends in phospholipid vesicles for the oral delivery of natural compounds. Liposomes have long been used as delivery systems, thanks to their ability to incorporate diverse bioactives, their biocompatibility and safety. However, the efficacy of oral liposomes is hampered by their low stability under the harsh conditions of the gastrointestinal tract. Different approaches have been utilized with the aim of improving the stability of liposomes and the payload after oral administration. This report provides an overview on the phospholipid vesicles used for oral delivery of natural compounds, exploring the current strategies to improve their performance by modifying the lipid bilayer composition and assembly or the physical state.

引用

页码：1795 / 1803

页数：9

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