Orthogonal Synthesis of Xeno Nucleic Acids

被引：7

作者：

Fiers, Guillaume ^{[1
]}

Chouikhi, Dalila ^{[1
,2
]}

Oswald, Laurence ^{[1
]}

Al Ouahabi, Abdelaziz ^{[1
]}

Chan-Seng, Delphine ^{[1
]}

Charles, Laurence ^{[3
]}

Lutz, Jean-Francois ^{[1
]}

机构：

[1] Inst Charles Sadron, Precis Macromol Chem Grp, 23 Rue Loess,BP84047, F-67034 Strasbourg, France

[2] Univ Abou Bekr Belkaid Tlemcen, Lab Catalyse & Synth Chim Organ, BP 119 Pole Imama Bat B, Tilimsen 13000, Algeria

[3] Aix Marseille Univ, Inst Rad Chem, CNRS, UMR 7273, Marseille, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 50期

关键词：

iterative chemistry; nucleic acids; orthogonal synthesis; sequence-controlled polymers; solid-phase synthesis; SOLID-PHASE SYNTHESIS; INFORMATION-CONTAINING MACROMOLECULES; DNA-TEMPLATED POLYMERIZATION; ENCODED OLIGOMERS; PEPTIDE BACKBONE; GENETIC POLYMERS; CLICK CHEMISTRY; PNA; SEGMENTS; PEPTOIDS;

D O I：

10.1002/chem.201604386

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sequence-defined peptide triazole nucleic acids (PTzNA) were synthesized by means of a solid-phase orthogonal "AB + CD" iterative strategy. In this approach, AB and CD building blocks containing carboxylic acid (A), azide (B), alkyne (C), and primary amine (D) functions are assembled together by successive copper-catalyzed azide-alkyne cycloaddition (CuAAC) and acid-amine coupling steps. Different PTzNA genetic sequences were prepared using a library of eight building blocks (i.e., four AB and four CD building blocks).

引用

页码：17945 / 17948

页数：4

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