Kidney injury molecule-1: More than just an injury marker of tubular epithelial cells?

被引:117
作者
Lim, Ai Ing [1 ]
Tang, Sydney C. W. [1 ]
Lai, Kar Neng [2 ]
Leung, Joseph C. K. [1 ]
机构
[1] Univ Hong Kong, Dept Med, Queen Mary Hosp, Pokfulam, Hong Kong, Peoples R China
[2] Hong Kong Sanat & Hosp, Nephrol Ctr, Happy Valley, Hong Kong, Peoples R China
关键词
ACUTE-RENAL-FAILURE; HEPATITIS-A VIRUS; PHOSPHATIDYLSERINE RECEPTOR; URINARY BIOMARKER; TUBULOINTERSTITIAL INJURY; TRANSPLANT RECIPIENTS; INTERSTITIAL FIBROSIS; DIABETIC-NEPHROPATHY; APOPTOTIC CELLS; IGA NEPHROPATHY;
D O I
10.1002/jcp.24267
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Regardless of the original causes and etiology, the progression to renal function declines follows a final common pathway associated with tubulointerstitial injury, in which the proximal tubular epithelial cells (PTEC) are instrumental. Kidney injury molecule-1 (KIM-1) is an emerging biomarker, and its expression and release are induced in PTEC upon injury. KIM-1 plays the role as a double-edged sword and implicates in the process of kidney injury and healing. Expression of KIM-1 is also associated with tubulointerstitial inflammation and fibrosis. More importantly, KIM-1 expressing PTEC play the role as the residential phagocytes, contribute to the removal of apoptotic cells and facilitate the regeneration of injured tubules. The precise mechanism of KIM-1 and its sheded ectodomain on restoration of tubular integrity after injury is not fully understood. Other than PTEC, macrophages (Mo) also implicate in tubular repair. Understanding the crosstalk between Mo and the injured PTEC is essential for designing appropriate methods for controlling the sophisticated machinery in tubular regeneration and healing. This article will review the current findings of KIM-1, beginning with its basic structure, utility as a biomarker, and possible functions, with focus on the role of KIM-1 in regeneration and healing of injured PTEC. J. Cell. Physiol. (C) 2013 Wiley Periodicals, Inc.
引用
收藏
页码:917 / 924
页数:8
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