Role of spinal NMDA and non-NMDA receptors in the pressor reflex response to abdominal ischemia

被引:3
|
作者
Gee, BY [1 ]
Tjen-a-Looi, SC [1 ]
Hill, JM [1 ]
Chahal, PS [1 ]
Longhurst, JC [1 ]
机构
[1] Univ Calif Irvine, Dept Med, Irvine, CA 92697 USA
关键词
6-nitro-7-sulfamylbenzo(f)quinoxaline-2,3-dione; dl-2-amino-5-phosphonopentanoate; alpha-chloralose; decerebrate;
D O I
10.1152/ajpregu.00297.2001
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Abdominal ischemia induces a pressor reflex caused mainly by C-fiber afferent stimulation. Because excitatory amino acids, such as glutamate, bind to N-methyl-D-aspartate (NMDA) and non-NMDA [dl-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)] receptors and serve as important spinal neurotransmitters, we hypothesized that both receptors play a role in the abdominal ischemia pressor reflex. In chloralose-anesthetized cats, NMDA receptor blockade with 25.0 mM dl-2-amino-5-phosphonopentanoate did not alter the pressor reflex (33 +/- 9 to 33 +/- 7 mmHg, P > 0.05, n = 4), whereas AMPA receptor blockade with 4.0 mM 6-nitro-7-sulfamylbenzo(f)quinoxaline-2,3-dione significantly attenuated the reflex (29 +/- 5 to 16 +/- 4 mmHg, P < 0.05, n = 6). Because several studies suggest that anesthesia masks the effects of glutamatergic receptors, this experiment was repeated on decerebrate cats, and in this group, NMDA receptor blockade with 25.0 mM dl-2-amino-5-phosphonopentanoate significantly altered the pressor reflex (36 +/- 3 to 25 +/- 4 mmHg, P > 0.05, n = 5). Our combined data suggest that spinal NMDA and AMPA receptors play a role in the abdominal ischemia pressor reflex.
引用
收藏
页码:R850 / R857
页数:8
相关论文
共 50 条
  • [31] Adult thalamocortical transmission involves both NMDA and non-NMDA receptors
    Gil, Z
    Amitai, Y
    JOURNAL OF NEUROPHYSIOLOGY, 1996, 76 (04) : 2547 - 2554
  • [32] Role of Ca2+-permeable non-NMDA glutamate receptors in spinal nociceptive transmission
    Stanfa, LC
    Hampton, DW
    Dickenson, AH
    NEUROREPORT, 2000, 11 (14) : 3199 - 3202
  • [33] IONOTROPIC GLUTAMATE RECEPTORS FOCUS ON NON-NMDA RECEPTORS
    JORGENSEN, M
    TYGESEN, CK
    ANDERSEN, PH
    PHARMACOLOGY & TOXICOLOGY, 1995, 76 (05): : 312 - 319
  • [34] A STUDY OF NON-NMDA RECEPTORS IN CHICK CEREBELLUM
    MANO, I
    PAPERNA, T
    DEVILLERSTHIERY, A
    GALZI, JL
    CHANGEUX, JP
    TEICHBERG, VI
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S13 - S13
  • [35] A STUDY OF NON-NMDA RECEPTORS IN CHICK CEREBELLUM
    MANO, I
    PAPERNA, T
    DEVILLERSTHIERY, A
    GALZI, JL
    CHANGEUX, JP
    TEICHBERG, VI
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S259 - S259
  • [36] NON-NMDA RECEPTORS IN AVIAN AND MAMMALIAN CEREBELLUM
    MITSACOS, A
    HATZIEFTHIMIOU, A
    ZAVITSANOU, K
    KOUVELAS, ED
    NEUROPSYCHOPHARMACOLOGY, 1993, 9 (02) : S158 - S159
  • [37] The organization and regulation of non-NMDA receptors in neurons
    Wenthold, RJ
    Roche, KW
    GLUTAMATE SYNAPSE AS A THERAPEUTICAL TARGET: MOLECULAR ORGANIZATION AND PATHOLOGY OF THE GLUTAMATE SYNAPSE, 1998, 116 : 133 - 152
  • [38] PRIMARY AFFERENT DEPOLARIZATION IN THE RAT SPINAL-CORD IS MEDIATED BY PATHWAYS UTILIZING NMDA AND NON-NMDA RECEPTORS
    EVANS, RH
    LONG, SK
    NEUROSCIENCE LETTERS, 1989, 100 (1-3) : 231 - 236
  • [39] Effects of intertrigeminal region NMDA and non-NMDA receptors on respiratory responses in rats
    Radulovacki, Miodrag
    Stoiljkovic, Milan
    Saponjic, Jasna
    Carley, David W.
    RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2007, 156 (01) : 40 - 46
  • [40] ROLE OF NMDA AND NON-NMDA RECEPTORS IN THE NUCLEUS-TRACTUS-SOLITARIUS IN THE DEPRESSANT EFFECT OF ETHANOL ON BAROREFLEXES
    ELMAS, MM
    ABDELRAHMAN, AA
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1993, 266 (02): : 602 - 610