Role of spinal NMDA and non-NMDA receptors in the pressor reflex response to abdominal ischemia

被引:3
|
作者
Gee, BY [1 ]
Tjen-a-Looi, SC [1 ]
Hill, JM [1 ]
Chahal, PS [1 ]
Longhurst, JC [1 ]
机构
[1] Univ Calif Irvine, Dept Med, Irvine, CA 92697 USA
关键词
6-nitro-7-sulfamylbenzo(f)quinoxaline-2,3-dione; dl-2-amino-5-phosphonopentanoate; alpha-chloralose; decerebrate;
D O I
10.1152/ajpregu.00297.2001
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Abdominal ischemia induces a pressor reflex caused mainly by C-fiber afferent stimulation. Because excitatory amino acids, such as glutamate, bind to N-methyl-D-aspartate (NMDA) and non-NMDA [dl-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)] receptors and serve as important spinal neurotransmitters, we hypothesized that both receptors play a role in the abdominal ischemia pressor reflex. In chloralose-anesthetized cats, NMDA receptor blockade with 25.0 mM dl-2-amino-5-phosphonopentanoate did not alter the pressor reflex (33 +/- 9 to 33 +/- 7 mmHg, P > 0.05, n = 4), whereas AMPA receptor blockade with 4.0 mM 6-nitro-7-sulfamylbenzo(f)quinoxaline-2,3-dione significantly attenuated the reflex (29 +/- 5 to 16 +/- 4 mmHg, P < 0.05, n = 6). Because several studies suggest that anesthesia masks the effects of glutamatergic receptors, this experiment was repeated on decerebrate cats, and in this group, NMDA receptor blockade with 25.0 mM dl-2-amino-5-phosphonopentanoate significantly altered the pressor reflex (36 +/- 3 to 25 +/- 4 mmHg, P > 0.05, n = 5). Our combined data suggest that spinal NMDA and AMPA receptors play a role in the abdominal ischemia pressor reflex.
引用
收藏
页码:R850 / R857
页数:8
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