Regulations of Retinal Inflammation: Focusing on Muller Glia

被引：27
作者：
Chen, Yingying
Xia, Qinghong
Zeng, Yue
Zhang, Yun
Zhang, Meixia
机构：
[1] Department of Ophthalmology, Sichuan University West China Hospital, Sichuan University, Chengdu
[2] Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu
[3] Operating Room of Anesthesia Surgery Center, West China Hospital, Sichuan University, Chengdu
[4] West China School of Nursing, Sichuan University, Chengdu
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷
关键词：
retinal inflammation; Muller glia; cytokines; miRNA; regeneration; EPITHELIUM-DERIVED FACTOR; DIABETIC-RETINOPATHY; GANGLION-CELLS; GM-CSF; COMPLEMENT EXPRESSION; MAMMALIAN TARGET; GENE-THERAPY; IN-VITRO; KAPPA-B; ACTIVATION;
D O I：
10.3389/fcell.2022.898652
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Retinal inflammation underlies multiple prevalent retinal diseases. While microglia are one of the most studied cell types regarding retinal inflammation, growing evidence shows that Muller glia play critical roles in the regulation of retinal inflammation. Muller glia express various receptors for cytokines and release cytokines to regulate inflammation. Muller glia are part of the blood-retinal barrier and interact with microglia in the inflammatory responses. The unique metabolic features of Muller glia in the retina makes them vital for retinal homeostasis maintenance, regulating retinal inflammation by lipid metabolism, purine metabolism, iron metabolism, trophic factors, and antioxidants. miRNAs in Muller glia regulate inflammatory responses via different mechanisms and potentially regulate retinal regeneration. Novel therapies are explored targeting Muller glia for inflammatory retinal diseases treatment. Here we review new findings regarding the roles of Muller glia in retinal inflammation and discuss the related novel therapies for retinal diseases.
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页数：15
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