Interferon induced with helicase C domain 1 (IFIH1): Trends on helicase domain and type 1 diabetes onset

被引：10
作者：
Moura, Ronald [1 ,3 ]
Araujo, Jacqueline [2 ]
Guimaraes, Rafael [1 ]
Crovella, Sergio [1 ,3 ]
Brandao, Lucas [1 ,4 ]
机构：
[1] Univ Fed Pernambuco, Lab Immunopathol Keizo Asami, Recife, PE, Brazil
[2] Univ Fed Pernambuco, Pediat Endocrinol Serv Clin Hosp, Recife, PE, Brazil
[3] Univ Fed Pernambuco, Dept Genet, Recife, PE, Brazil
[4] Univ Fed Pernambuco, Dept Pathol, Recife, PE, Brazil
来源：
GENE | 2013年 / 516卷 / 01期
关键词：
Enterovirus response; Autoimmune diseases; Genetic susceptibility; Single nucleotide polymorphism; GRAVES-DISEASE; RIG-I; VIRUSES; LOCUS; AUTOIMMUNITY; POLYMORPHISM; THYROIDITIS; INFECTIONS; VARIANTS; ETIOLOGY;
D O I：
10.1016/j.gene.2012.11.066
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The Interferon-induced with helicase C domain 1 (IFIH1) gene has been hypothesized as involved in the viral etiology of type 1 diabetes (T1D) and other autoimmune disorders, since it is implicated in viral recognition. In our study we analyzed IFIH1 rs6432714 and rs10930046 SNPs in T1D patients stratified for the presence of celiac disease and autoimmune thyroid disease. No association with susceptibility to develop the diseases was found. The rs6432714, a tag-SNP that represents part of helicase domain of IF1H1 protein showed a trend of association only with T1D development (P>0.025 after Bonferroni adjustment) in log-additive model (OR=1.45, P=0.0365, power=0.99), indicating that helicase domain of IFIH1 protein could be associated with the susceptibility to T1D. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：66 / 68
页数：3
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