Substituted 3(2H)-Furanones by a Tandem Michael Addition/Palladium-Catalyzed Ring-Closing Protocol

被引：14

作者：

John, Jubi ^{[1
]}

Hopf, Henning ^{[1
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Organ Chem, D-38106 Braunschweig, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 05期

关键词：

Homogeneous catalysis; Palladium; Domino reactions; Michael addition; Oxygen heterocycles; BULLATENONE; DERIVATIVES; JATROPHONE;

D O I：

10.1002/ejoc.201201253

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel palladium-catalyzed route for the synthesis of substituted 3(2H)-furanones from activated alkenes and 4-chloroacetoacetate was developed. The first step of the tandem reaction is the Michael addition of an acetoacetate to the alkene followed by palladium-catalyzed ring closure of the ad-duct to form the furanone. The reaction was extended to a number of substituted alkenes, and the corresponding substituted 3(2H)-furanones were obtained in good to excellent yields.

引用

页码：841 / 845

页数：5

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