Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila

被引：291
作者：
Franc, NC
Heitzler, P
Ezekowitz, RAB
White, K [1 ]
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Lab Dev Immunol, Charlestown, MA 02129 USA
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Pediat, Charlestown, MA 02129 USA
[4] Univ Strasbourg 1, CNRS, INSERM, IGBMC, F-67404 Illkirch Graffenstaden, France
来源：
SCIENCE | 1999年 / 284卷 / 5422期
关键词：
D O I：
10.1126/science.284.5422.1991
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.
引用
收藏
页码：1991 / 1994
页数：4
相关论文
共 38 条
[1]   MACROPHAGES IN DROSOPHILA EMBRYOS AND L2 CELLS EXHIBIT SCAVENGER RECEPTOR-MEDIATED ENDOCYTOSIS [J].
ABRAMS, JM ;
LUX, A ;
STELLER, H ;
KRIEGER, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10375-10379
[2]  
Ashburner M., 1989, DROSOPHILA LAB MANUA
[3]  
BOEDIGHEIMER M, 1993, DEVELOPMENT, V118, P1291
[4]   grim, a novel cell death gene in Drosophila [J].
Chen, P ;
Nordstrom, W ;
Gish, B ;
Abrams, JM .
GENES & DEVELOPMENT, 1996, 10 (14) :1773-1782
[5]   Human CD14 mediates recognition and phagocytosis of apoptotic cells [J].
Devitt, A ;
Moffatt, OD ;
Raykundalia, C ;
Capra, JD ;
Simmons, DL ;
Gregory, CD .
NATURE, 1998, 392 (6675) :505-509
[6]   Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression [J].
Dimarcq, JL ;
Imler, JL ;
Lanot, R ;
Ezekowitz, RAB ;
Hoffmann, JA ;
Janeway, CA ;
Lagueux, M .
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1997, 27 (10) :877-886
[7]  
ENDEMANN G, 1993, J BIOL CHEM, V268, P11811
[8]   Elements of immunity - The instructive role of innate immunity in the acquired immune response [J].
Fearon, DT ;
Locksley, RM .
SCIENCE, 1996, 272 (5258) :50-54
[9]   Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells [J].
Franc, NC ;
Dimarcq, JL ;
Lagueux, M ;
Hoffmann, J ;
Ezekowitz, RAB .
IMMUNITY, 1996, 4 (05) :431-443
[10]   Phagocytosis and development: back to the future [J].
Franc, NC ;
White, K ;
Ezekowitz, RAB .
CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (01) :47-52
1234