The RSK family of kinases: emerging roles in cellular signalling

被引：601

作者：

Anjum, Rana ^{[1
]}

Blenis, John ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 10期

关键词：

D O I：

10.1038/nrm2509

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras-extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signalling cascade. Significant advances in the field of RSK and ERK/MAPK signalling have occurred in the past few years, including biological insights and the discovery of novel substrates and new RSK regulatory mechanisms. Collectively, these data expand the current models of RSK signalling and highlight potential directions of research in RSK-mediated survival, growth, proliferation and migration.

引用

页码：747 / 758

页数：12

共 122 条

[1] Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes:: A possible factor regulating synaptic protein synthesis [J].

Angenstein, F ;

Greenough, WT ;

Weiler, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :15078-15083

[2] The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling [J].

Anjum, R ;

Roux, PP ;

Ballif, BA ;

Gygi, SP ;

Blenis, J .

CURRENT BIOLOGY, 2005, 15 (19) :1762-1767

[3] MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells [J].

Arthur, JSC ;

Cohen, P .

FEBS LETTERS, 2000, 482 (1-2) :44-48

[4] Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins [J].

Arthur, JSC ;

Fong, AL ;

Dwyer, JM ;

Davare, M ;

Reese, E ;

Obrietan, K ;

Impey, S .

JOURNAL OF NEUROSCIENCE, 2004, 24 (18) :4324-4332

[5] The selectivity of protein kinase inhibitors: a further update [J].

Bain, Jenny ;

Plater, Lorna ;

Elliott, Matt ;

Shpiro, Natalia ;

Hastie, C. James ;

Mclauchlan, Hilary ;

Klevernic, Iva ;

Arthur, J. Simon C. ;

Alessi, Dario R. ;

Cohen, Philip .

BIOCHEMICAL JOURNAL, 2007, 408 :297-315

[6]

Ballif BA, 2001, CELL GROWTH DIFFER, V12, P397

[7] A large-scale RNAi screen in human cells identifies new components of the p53 pathway [J].

Berns, K ;

Hijmans, EM ;

Mullenders, J ;

Brummelkamp, TR ;

Velds, A ;

Heimerikx, M ;

Kerkhoven, RM ;

Madiredjo, M ;

Nijkamp, W ;

Weigelt, B ;

Agami, R ;

Ge, W ;

Cavet, G ;

Linsley, PS ;

Beijersbergen, RL ;

Bernards, R .

NATURE, 2004, 428 (6981) :431-437

[8] The protein kinase p90 Rsk as an essential mediator of cytostatic factor activity [J].

Bhatt, RR ;

Ferrell, JE .

SCIENCE, 1999, 286 (5443) :1362-1365

[9] RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer [J].

Bignone, P. A. ;

Lee, K. Y. ;

Liu, Y. ;

Emilion, G. ;

Finch, J. ;

Soosay, A. E. R. ;

Charnock, F. M. L. ;

Beck, S. ;

Dunham, I. ;

Mungall, A. J. ;

Ganesan, T. S. .

ONCOGENE, 2007, 26 (05) :683-700

[10] DIVERGENT FUNCTIONAL ROLES FOR P90(RSK) KINASE DOMAINS [J].

BJORBAEK, C ;

ZHAO, Y ;

MOLLER, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (32) :18848-18852

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