Polymorphism of human haptoglobin and its clinical importance

被引：48

作者：

de Albuquerque Wobeto, Vania Peretti ^{[1
]}

Zaccariotto, Tania Regina ^{[1
]}

Sonati, Maria de Fatima ^{[1
]}

机构：

[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083970 Campinas, SP, Brazil

来源：

GENETICS AND MOLECULAR BIOLOGY | 2008年 / 31卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

haptoglobin; hemoglobin; genetic polymorphisms;

D O I：

10.1590/S1415-47572008000400002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.

引用

页码：602 / 620

页数：19

共 207 条

[1]

ABBAS AK, 2003, CELLULAR MOL IMMUNOL, P65

[2] Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release [J].