Combining fundamental knowledge and latent variable techniques to transfer process monitoring models between plants

被引:21
作者
Tomba, Emanuele [1 ]
Faccoa, Pierantonio [1 ]
Bezzo, Fabrizio [1 ]
Garcia-Munoz, Salvador [2 ]
Barolo, Massimiliano [1 ]
机构
[1] Univ Padua, Dipartimento Ingn Ind, Comp Aided Proc Engn Lab, CAPE Lab, I-35131 Padua, PD, Italy
[2] Pfizer Worldwide R&D, Groton, CT 06340 USA
关键词
Model transfer; Process monitoring; JY-PLS; Quality-by-design; PAT; Scale-up; Design space; BATCH PROCESSES; METHODOLOGY; ALGORITHMS; DESIGN;
D O I
10.1016/j.chemolab.2012.04.016
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
In this paper we explore the issue of the transfer of process monitoring models between different plants that exploit the same manufacturing process to manufacture the same product. Given a source plant A and a target plant B, the objective is to use the data available from plant A to monitor the operation of plant B, until a sufficient amount of data entirely representative of the operation in plant B is collected to allow building a process monitoring model based on these data only. Two different model transfer methodologies are proposed, which depend on the nature of the measured process variables (namely, on whether they are common between the two plants or not). Both the proposed approaches combine fundamental engineering knowledge on the system (derived from mass or energy balances) with latent variable modeling techniques (namely, principal component analysis and joint-Y partial least-squares regression). Both approaches are based on adaptive algorithms, which make them practical for online use, and are tested on a benchmark problem related to the scale-up of the monitoring model for an industrial spray-drying process. Results show that both proposed procedures provide robust and prompt fault detection, even when very few data are available from plant B. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:67 / 77
页数:11
相关论文
共 34 条
[1]  
[Anonymous], 1991, A User's Guide to Principal Components
[2]  
[Anonymous], 1989, MULTIVARIATE CALIBRA
[3]   Nonlinear process monitoring using JITL-PCA [J].
Cheng, C ;
Chiu, MS .
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2005, 76 (01) :1-13
[4]   A Model-Based Methodology for Spray-Drying Process Development [J].
Dobry, Dan E. ;
Settell, Dana M. ;
Baumann, John M. ;
Ray, Rod J. ;
Graham, Lisa J. ;
Beyerinck, Ron A. .
JOURNAL OF PHARMACEUTICAL INNOVATION, 2009, 4 (03) :133-142
[5]   Transfer of Process Monitoring Models between Different Plants Using Latent Variable Techniques [J].
Facco, Pierantonio ;
Tomba, Emanuele ;
Bezzo, Fabrizio ;
Garcia-Munoz, Salvador ;
Barolo, Massimiliano .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2012, 51 (21) :7327-7339
[6]   Nearest-Neighbor Method for the Automatic Maintenance of Multivariate Statistical Soft Sensors in Batch Processing [J].
Facco, Pierantonio ;
Bezzo, Fabrizio ;
Barolo, Massimiliano .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2010, 49 (05) :2336-2347
[7]  
Feundale RN, 2002, CHEMOMETR INTELL LAB, V64, P181
[8]  
Food and Drug Administration, 2004, HFD240 FDA CTR DRUG
[9]   Correlation-based spectral clustering for flexible process monitoring [J].
Fujiwara, Koichi ;
Kano, Manabu ;
Hasebe, Shinji .
JOURNAL OF PROCESS CONTROL, 2011, 21 (10) :1438-1448
[10]   Development of correlation-based clustering method and its application to software sensing [J].
Fujiwara, Koichi ;
Kano, Manabu ;
Hasebe, Shinji .
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2010, 101 (02) :130-138