3D printing of PLGA scaffolds for tissue engineering

被引：47

作者：

Mironov, Anton V. ^{[1
]}

Grigoryev, Aleksey M. ^{[2
]}

Krotova, Larisa I. ^{[1
]}

Skaletsky, Nikolaj N. ^{[2
]}

Popov, Vladimir K. ^{[1
]}

Sevastianov, Viktor I. ^{[2
]}

机构：

[1] Fed Res Ctr Chrystallog & Photon, Insitute Photon Technol, Moscow, Russia

[2] Russian Federat, Acad VI Shumakov Fed Res Ctr Transplantol & Artif, Minist Hlth, Moscow, Russia

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2017年 / 105卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

bioresorbable polymeric scaffolds; tissue engineering; 3D printing; polylactic-co-glycolic acids; BIOMATERIALS;

D O I：

10.1002/jbm.a.35871

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We proposed a novel method of generation of bioresorbable polymeric scaffolds with specified architectonics for tissue engineering using extrusion three-dimensional (3D) printing with solutions of polylactoglycolide in tetraglycol with their subsequent solidifying in aqueous medium. On the basis of 3D computer models, we obtained the matrix structures with interconnected system of pores ranging in size from 0.5 to 500 mu m. The results of in vitro studies using cultures of line NIH 3?3 mouse fibroblasts, floating islet cultures of newborn rabbit pancreas, and mesenchymal stem cells of human adipose tissue demonstrated the absence of cytotoxicity and good adhesive properties of scaffolds in regard to the cell cultures chosen. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 104-109, 2017.

引用

页码：104 / 109

页数：6

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