Comparison of polyethylene glycol 3350 and lactulose for treatment of chronic constipation in children

被引：80

作者：

Gremse, DA ^{[1
]}

Hixon, J ^{[1
]}

Crutchfield, A ^{[1
]}

机构：

[1] Univ S Alabama, Div Pediat Gastroenterol & Nutr, Coll Med, Mobile, AL 36604 USA

来源：

CLINICAL PEDIATRICS | 2002年 / 41卷 / 04期

关键词：

D O I：

10.1177/000992280204100405

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Polyethylene glycol (PEG) 3350 and lactulose were compared in an unblinded, randomized, crossover design for treatment of constipation in 37 children aged 2 to 16 years. Subjects received lactulose (1.3 g/kg/d divided twice daily up to 20 g) or PEG 3350 (10 g/m(2)/day) for 2 weeks. PEG 3350 significantly decreased the total colonic transit time compared to lactulose (47.6 +/-2.7 vs 55.3 +/-2.4 hours, mean SE, PEG 3350 vs lactulose, respectively, p = 0.038). The stool frequency, form, and the ease of passage were similar for each laxative. Polyethylene glycol 3350 is an effective laxative for the treatment of chronic constipation in children.

引用

页码：225 / 229

页数：5

共 19 条

[11] ASSESSMENT OF THE REPRODUCIBILITY OF THE LACTULOSE H-2 BREATH TEST AS A MEASURE OF MOUTH TO CECUM TRANSIT-TIME [J].

LABROOY, SJ ;

MALE, PJ ;

BEAVIS, AK ;

MISIEWICZ, JJ .

GUT, 1983, 24 (10) :893-896

[12]

LEVINE MD, 1975, PEDIATRICS, V56, P412

[13] Practical approach to defecation disorders in children [J].

Lewis, LG ;

Rudolph, CD .

PEDIATRIC ANNALS, 1997, 26 (04) :260-268

[14] CHRONIC CONSTIPATION IN CHILDREN [J].

LOENINGBAUCKE, V .

GASTROENTEROLOGY, 1993, 105 (05) :1557-1564

[15] Simplified Assessment of Segmental Colonic Transit [J].

Metcalf, Amanda M. ;

Phillips, Sidney F. ;

Zinsmeister, Alan R. ;

MacCarty, Robert L. ;

Beart, Robert W. ;

Wolff, Bruce G. .

GASTROENTEROLOGY, 1987, 92 (01) :40-47

[16] ANORECTAL MANOMETRY RESULTS IN DEFECATION DISORDERS [J].

MOLNAR, D ;

TAITZ, LS ;

URWIN, OM ;

WALES, JKH .

ARCHIVES OF DISEASE IN CHILDHOOD, 1983, 58 (04) :257-261

[17] RANDOMIZED TRIAL OF LAXATIVES IN TREATMENT OF CHILDHOOD ENCOPRESIS [J].

NOLAN, T ;

DEBELLE, G ;

OBERKLAID, F ;

COFFEY, C .

LANCET, 1991, 338 (8766) :523-527

[18]

PASBANKAR DS, 2001, J PEDIAT, V139, P428

[19] SAFETY, EFFICACY, AND TOLERANCE OF INTESTINAL LAVAGE IN PEDIATRIC-PATIENTS UNDERGOING DIAGNOSTIC COLONOSCOPY [J].

SONDHEIMER, JM ;

SOKOL, RJ ;

TAYLOR, SF ;

SILVERMAN, A ;

ZELASNEY, B .

JOURNAL OF PEDIATRICS, 1991, 119 (01) :148-152

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