Controlled drug delivery of antileishmanial chalcones from Layer-by-Layer (LbL) self assembled PSS/PDADMAC thin films

被引：20

作者：

Bhalerao, Uma M. ^{[1
]}

Acharya, Jyotiranjan ^{[1
]}

Halve, Anand K. ^{[2
]}

Kaushik, Mahabir Parshad ^{[1
]}

机构：

[1] Def R&D Estab, Proc Technol Dev Div, Gwalior 474002, Madhya Pradesh, India

[2] Jiwaji Univ, Sch Studies Chem, Gwalior, Madhya Pradesh, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 10期

关键词：

ULTRATHIN MULTILAYER FILMS; RELEASE KINETICS; IN-VITRO; ADSORPTION; MICROCAPSULES; LEISHMANIASIS; THERAPY; POLYELECTROLYTES; ENCAPSULATION; BUILDUP;

D O I：

10.1039/c3ra44611e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Layer-by-Layer (LbL) approach was applied for the encapsulation of antileishmanial drugs viz. chalcones (3-mB-4'-HC and 3-DC-4'-HC) to study their release properties at pH 7.4 from a polyelectrolyte self assembled multilayer thin film. The LbL self assembly was achieved by alternate adsorption of oppositely charged polyelectrolytes, poly(styrene-4-sulfonic acid) sodium salt (PSS) and poly(diallyldimethylammonium) chloride (PDADMAC) on planar quartz substrate. The growth of the multilayer self assembly as well as loading and release of the drugs were studied by UV-Visible spectroscopy. Both the chalcones, 3-mB-4'-HC and 3-DC-4'-HC have shown controlled and sustained release up to 224 and 824 minutes respectively. Kinetic fitting of the data confirmed that the process of drug release from the self assembly followed pseudo second order kinetics (R-2 >= 0.99).

引用

页码：4970 / 4977

页数：8

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