Therapeutic potential of gossypol: An overview

被引：105

作者：

Keshmiri-Neghab, Hoda ^{[1
]}

Goliaei, Bahram ^{[1
]}

机构：

[1] Univ Tehran, IBB, Lab Biophys & Mol Biol, Tehran, Iran

来源：

PHARMACEUTICAL BIOLOGY | 2014年 / 52卷 / 01期

关键词：

Antiapoptotic; antifertility; antimicrobial; antioxidant; antiparasitic; antitumor; antivirus; ANTIFERTILITY AGENT; INHIBITION; (-)-GOSSYPOL; ANTIOXIDANT; CELLS; DERIVATIVES; CARCINOMA; ENZYMES; PROTEIN; GROWTH;

D O I：

10.3109/13880209.2013.832776

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Context: Polyphenols are naturally occurring compounds found in fruits, vegetables, cereals, and beverages. Polyphenols occupy a unique place in biological science for their pharmacological properties. Gossypol is a polyphenolic compound that has attracted attention because of its biological effects. Objective: Gossypol is reported to exhibit antifertility, antioxidant, anticancer, antivirus, antiparasitic, and antimicrobial properties and lower plasma cholesterol. These are summarized with attention to the mechanisms of activity. Methods: This review summarizes the results of studies obtained in a comprehensive search of ScienceDirect, PubMed, Scirus, and Web of Science. Results and conclusion: The results of these studies provide a comprehensive understanding of the biological action of gossypol and its potential for the prevention of and therapy for resistant tumors and chronic human diseases such as HIV, malaria, and psoriasis.

引用

页码：124 / 128

页数：5

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