Novel Polyomavirus associated with Brain Tumors in Free-Ranging Raccoons, Western United States

被引：44

作者：

Dela Cruz, Florante N., Jr. ^{[1
]}

Giannitti, Federico ^{[2
]}

Li, Linlin ^{[3
]}

Woods, Leslie W. ^{[2
]}

Del Valle, Luis ^{[4
]}

Delwart, Eric ^{[3
,5
]}

Pesavento, Patricia A. ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA

[2] Univ Calif Davis, Davis, CA 95616 USA

[3] Blood Syst Res Inst, San Francisco, CA USA

[4] Louisiana State Univ, New Orleans, LA USA

[5] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 01期

关键词：

SMALL-T-ANTIGEN; JC; SV40; ONCOGENICITY; ASTROCYTOMA; INDUCTION; INFECTION; WILDLIFE; CANCER;

D O I：

10.3201/eid1901.121078

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumors of any type are exceedingly rare in raccoons. High-grade brain tumors, consistently located in the frontal lobes and olfactory tracts, were detected in 10 raccoons during March 2010 May 2012 in California and Oregon, suggesting an emerging, infectious origin. We have identified a candidate etiologic agent, dubbed raccoon polyomavirus, that was present in the tumor tissue of all affected animals but not in tissues from 20 unaffected animals. Southern blot hybridization and rolling circle amplification showed the episomal viral genome in the tumors. The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons.

引用

页码：77 / 84

页数：8

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