Role of YAP as a Mechanosensing Molecule in Stem Cells and Stem Cell-Derived Hematopoietic Cells

被引：12
作者：
Damkham, Nattaya [1 ]
Issaragrisil, Surapol [1 ,2 ,3 ]
Lorthongpanich, Chanchao [1 ]
机构：
[1] Mahidol Univ, Fac Med Siriraj Hosp, Siriraj Ctr Excellence Stem Cell Res, Bangkok 10700, Thailand
[2] Mahidol Univ, Fac Med Siriraj Hosp, Dept Med, Div Hematol, Bangkok 10700, Thailand
[3] Wattanosoth Hosp, Bangkok Hematol Ctr, BDMS Ctr Excellence Canc, Bangkok 10310, Thailand
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 23期
关键词：
YAP; stem cells; differentiation; hematopoietic stem cells; mechanical forces; mechanosensing; COMMON LYMPHOID PROGENITORS; HIPPO SIGNALING PATHWAY; LINEAGE COMMITMENT; ORGAN SIZE; CHONDROCYTE DIFFERENTIATION; CONTACT INHIBITION; BONE-MARROW; DROSOPHILA; TAZ; YAP/TAZ;
D O I：
10.3390/ijms232314634
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ) are transcriptional coactivators in the Hippo signaling pathway. Both are well-known regulators of cell proliferation and organ size control, and they have significant roles in promoting cell proliferation and differentiation. The roles of YAP and TAZ in stem cell pluripotency and differentiation have been extensively studied. However, the upstream mediators of YAP and TAZ are not well understood. Recently, a novel role of YAP in mechanosensing and mechanotransduction has been reported. The present review updates information on the regulation of YAP by mechanical cues such as extracellular matrix stiffness, fluid shear stress, and actin cytoskeleton tension in stem cell behaviors and differentiation. The review explores mesenchymal stem cell fate decisions, pluripotent stem cells (PSCs), self-renewal, pluripotency, and differentiation to blood products. Understanding how cells sense their microenvironment or niche and mimic those microenvironments in vitro could improve the efficiency of producing stem cell products and the efficacy of the products.
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页数：19
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