Nataxazole, a New Benzoxazole Derivative with Antitumor Activity Produced by Streptomyces sp Tu 6176

被引：63

作者：

Sommer, Patricia S. N. ^{[2
]}

Almeida, Rosemary C. ^{[2
]}

Schneider, Kathrin ^{[4
]}

Beil, Winfried ^{[3
]}

Suessmuth, Roderich D. ^{[4
]}

Fiedler, Hans-Peter ^{[1
]}

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Univ Fed Rio Grande do Norte, Ctr Biociencias, BR-59078970 Natal, RN, Brazil

[3] Hannover Med Sch, Inst Pharmakol, D-30625 Hannover, Germany

[4] Tech Univ Berlin, FG Organ Chem, Inst Chem, D-10623 Berlin, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 11期

关键词：

benzoxazole derivative; HPLC-diode array screening; antitumor activity; structure elucidation; Streptomyces;

D O I：

10.1038/ja.2008.97

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The new benzoxazole derivative nataxazole was isolated from Streptomyces sp. (strain Tu 6176). Nataxazole is related in structure to the potent antitumor compounds UK-1 and AJI9561 and showed similar strong growth inhibitory activity against various human tumor cell lines.

引用

页码：683 / 686

页数：4

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