A retrospective study of long-term outcomes in 152 patients with primary Sjogren's syndrome: 25-year experience

被引：50
作者：
Abrol, Esha [1 ]
Gonzalez-Pulido, Cristina [2 ]
Praena-Fernandez, Juan M. [3 ]
Isenberg, David A. [4 ]
机构：
[1] UCL, Sch Med, London W1N 8AA, England
[2] Univ Hosp Virgen del Rocio, Dept Internal Med, Seville, Spain
[3] Univ Hosp Virgen del Rocio, Methodol & Res Evaluat Unit, Andalusian Publ Fdn Hlth Res Management, Seville, Spain
[4] UCL, Ctr Rheumatol Res, Div Med, London, England
来源：
CLINICAL MEDICINE | 2014年 / 14卷 / 02期
关键词：
Sjogren's syndrome; long-term follow-up; autoimmune diseases; non-Hodgkin's lymphoma; neoplasia; LYMPHOMA DEVELOPMENT; FOLLOW-UP; AUTOIMMUNE-DISEASES; CLASSIFICATION; PREDICTORS; MORTALITY; COHORT; RISK;
D O I：
10.7861/clinmedicine.14-2-157
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The objective of this study was to evaluate the 25-year outcome of patients with primary Sjogren's syndrome (pSS). One hundred and fifty-two patients diagnosed with pSS (American European classification criteria) were retrospectively and descriptively analysed (1986-2011). Of all 152 patients, 55.9% were alive, 18.4% had died and 25.7% discontinued follow-up (mostly due to old age). Malignancy affected 28.3% and non-Hodgkin's lymphoma (NHL) affected 10.5%. The adjusted risk for development of NHL was an odds ratio (OR) of 10.5(95% confidence interval [CI]: 3.05-36.42) in patients with vasculitis (p<0.001), and OR 3.4 (95% CI 1.05-11.2) in the presence of glandular complications (parotid swelling, lymphadenopathy) (p=0.041). Seventy-five patients (49.3%) developed other autoimmune diseases (autoimmune thyroid disease [15.8%], pulmonary fibrosis [7.2%] and vasculitis [10.5%]). Although the course of pSS is relatively benign, over 25 years patients experience more clinical complications than previously described. In addition, vasculitis and glandular manifestations were significant predictors for NHL.
引用
收藏
页码：157 / 164
页数：8
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