Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma

被引：40

作者：

Omoto, Itaru ^{[1
]}

Matsumoto, Masataka ^{[1
]}

Okumura, Hiroshi ^{[1
]}

Uchikado, Yasuto ^{[1
]}

Setoyama, Tetsuro ^{[1
]}

Kita, Yoshiaki ^{[1
]}

Owaki, Tetsuhiro ^{[1
]}

Kijima, Yuko ^{[1
]}

Shinchi, Hiroyuki ^{[1
]}

Ishigami, Sumiya ^{[1
]}

Ueno, Shinichi ^{[1
]}

Natsugoe, Shoji ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Med, Dept Digest Surg Breast & Thyroid Surg, Kagoshima 8908520, Japan

来源：

ONCOLOGY LETTERS | 2014年 / 7卷 / 04期

关键词：

esophageal cancer; vascular endothelial growth factor-C; microlymphatic vessel density; vascular endothelial growth factor receptor-3; LYMPHATIC VESSEL DENSITY; VEGF-C; TUMOR LYMPHANGIOGENESIS; VEGF-C/VEGFR-3; AXIS; PROSTATE-CANCER; FACTOR (VEGF)-C; METASTASIS; INVASION; D2-40; ANGIOGENESIS;

D O I：

10.3892/ol.2014.1823

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lymph node metastasis is one of the most important prognostic factors in esophageal squamous cell carcinoma (ESCC). Vascular endothelial growth factor (VEGF)-C and its receptor, VEGF receptor-3 (VEGFR-3), are key in the process of lymphangiogenesis. The present study immunohistochemically examined the expression of VEGF-C, VEGFR-3 and D2-40 in 119 patients with ESCC, and microlymphatic vessel density (MLVD) was calculated based on D2-40 expression counts. Positive expression of VEGF-C was found to correlate significantly with depth of tumor invasion, lymphatic invasion and lymph node metastasis (P<0.001, P<0.0001 and P<0.0001, respectively). Patients with deeper tumor invasion showed higher positivity of VEGFR-3 expression (P<0.05), while patients with lymph node metastasis showed higher MLVD (P<0.05). When patients were divided into three groups according to the expression of VEGF-C and VEGFR-3, patients with coexpression of VEGF-C and VEGFR-3 exhibited poorer prognosis and higher MLVD. The VEGF-C/VEGFR-3 axis is important in tumor lymphangiogenesis.

引用

页码：1027 / 1032

页数：6

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