Coumarin-derived Fe3+-selective fluorescent turn-off chemosensors: synthesis, properties, and applications in living cells

被引：78

作者：

En, Da ^{[1
]}

Guo, Yuan ^{[1
,2
]}

Chen, Bo-Ting ^{[3
]}

Dong, Biao ^{[3
]}

Peng, Meng-Jiao ^{[1
]}

机构：

[1] NW Univ Xian, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Peoples R China

[2] Univ Orleans, Inst Chim Organ & Analyt, F-45067 Orleans 2, France

[3] Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 01期

基金：

中国国家自然科学基金;

关键词：

CARRIER SYSTEM; SENSOR; CU2+; FE3+; IRON; ION; RECOGNITION; COMPLEXES; CANCER;

D O I：

10.1039/c3ra44843f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel coumarin-based fluorogenic probe bearing the tris unit (DAT-1) with high selectivity and suitable affinity toward Fe3+ over other cations tested was developed in biological systems. The sensing mechanism was studied by quantum calculations. The probe can be applied to the monitoring of Fe3+ in aqueous solution with a pH span of 3-8. In addition, biological imaging, membrane permeability and nontoxicity demonstrate that DAT-1 could act as a turn-off fluorescent chemosensor for Fe3+ in living cells.

引用

页码：248 / 253

页数：6

共 35 条

[1] Effect of natural and synthetic estrogens on A549 lung cancer cells: Correlation of chemical structures with cytotoxic effects [J].