Copper-Catalyzed Aryltrifluoromethylation of N-Phenylcinnamamides: Access to Trifluoromethylated 3,4-Dihydroquinolin-2(1H)-ones

被引：24

作者：

Wang, Qiang ^{[1
]}

Han, Guifang ^{[1
]}

Liu, Yuxiu ^{[1
]}

Wang, Qingmin ^{[1
]}

机构：

[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 11期

基金：

中国国家自然科学基金;

关键词：

aryltrifluoromethylation; copper; diastereoselectivity; regioselectivity; Togni's reagent; BOND FORMATION; ALPHA-TRIFLUOROMETHYLATION; DEAROMATIZATION ACCESS; FLUORINE; DERIVATIVES; ALKENES; CONSTRUCTION; CONSTITUENTS; 2-QUINOLONES; CYCLIZATION;

D O I：

10.1002/adsc.201500261

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A method for copper-catalyzed aryltrifluoromethylation of N-phenylcinnamamides is reported. This method provides a straightforward route to a variety of CF3-containing 3,4-dihydroquinolin-2(1H)-ones with excellent regioselectivity and diastereoselectivity.

引用

页码：2464 / 2468

页数：5

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